拉氧头孢

更新时间：2024-01-01 19:44:31

拉氧头孢结构式	常用名	拉氧头孢	英文名	Latamoxef
	CAS号	64952-97-2	分子量	520.47300
	密度	1.77 g/cm3	沸点	836ºC
	分子式	C₂₀H₂₀N₆O₉S	熔点	117 - 122ºC
	MSDS	美版	闪点	N/A

拉氧头孢用途

莫沙内酰胺(Latamoxef)是一种合成的氧-β-内酰胺抗生素。内酰胺对革兰氏阳性和革兰氏阴性需氧和厌氧细菌具有广泛的活性。莫沙内酰胺抑制β-内酰胺酶的产生[1]。

中文名	拉氧头孢
英文名	moxalactam
中文别名	7-((羧基(4-羟基苯基)乙酰)氨基)-7-甲氧基-(3-((1-甲基-1H-四唑-5-基)硫)甲基)-8-氧代-5-氧杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 \| 头霉拉坦
英文别名	更多

描述	莫沙内酰胺(Latamoxef)是一种合成的氧-β-内酰胺抗生素。内酰胺对革兰氏阳性和革兰氏阴性需氧和厌氧细菌具有广泛的活性。莫沙内酰胺抑制β-内酰胺酶的产生[1]。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
靶点	β-lactamases[1]
体外研究	莫沙内酰胺(Latamoxef)抑制90%的大肠杆菌、克雷伯菌属、变形杆菌属、Morganella morganii、淋病奈瑟菌、脑膜炎奈瑟菌、流感嗜血杆菌和沙门氏菌属菌株,包括浓度低于1μg/mL时对头孢噻吩(HY-B1275A)和庆大霉素(HY-A0276A)耐药的菌株[1]。莫沙内酰胺对铜绿假单胞菌具有中等活性,通常对其他假单胞杆菌具有活性,不动杆菌通常对莫沙内酮具有耐药性[1]。莫沙内酰胺在体外对多种β-内酰胺酶(包括脆弱芽孢杆菌产生的酶)具有显著的稳定性,可抑制β-内糖酶的产生,且不会诱导I类β-内酯酶[1]。
体内研究	莫沙内酰胺(Latamoxef)(0-7.4 mg/小鼠；皮下注射；一次)对小鼠细菌感染有效[2]。动物模型：4周龄雄性ICR小鼠,体重18-20g,细菌感染模型[2]剂量：0-7.4mg/小鼠给药：皮下注射,一次。结果：ED50s小于7.4mg/鼠对革兰氏阳性和革兰氏阴性细菌感染小鼠具有保护作用。
参考文献	[1]. Carmine AA, et al. Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1983 Oct;26(4):279-333. [2]. Goto S. In vitro and in vivo antibacterial activity of moxalactam, an oxa-β-lactam antibiotic. Clinical Infectious Diseases, 1982, 4(Supplement_3): S501-S510.

密度	1.77 g/cm3
沸点	836ºC
熔点	117 - 122ºC
分子式	C₂₀H₂₀N₆O₉S
分子量	520.47300
精确质量	520.10100
PSA	231.60000
折射率	1.768
储存条件	-20°C，密闭，干燥

拉氧头孢毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	RN6824500

A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity.

Antimicrob. Agents Chemother. 56(10) , 5157-63, (2012)

New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM-1 has a broad spectrum...

Comparison of cefoxitin and moxalactam 30 microg disc diffusion methods for detection of methicillin resistance in coagulase-negative staphylococci.

J. Antimicrob. Chemother. 59(4) , 763-6, (2007)

To compare cefoxitin and/or moxalactam 30 microg disc diffusion (DD) methods to detect methicillin resistance in coagulase-negative staphylococci (CoNS) using both high- and low-density (HD/LD) inocul...

Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells.

J. Antimicrob. Chemother. 49(2) , 315-20, (2002)

Viable Escherichia coli cells were entrapped in agar gel layers and incubated in a phosphate-limited glucose medium. Immobilized bacteria displayed enhanced alkaline phosphatase activity and overexpre...

5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid,7-((carboxy(4-hydroxyphenyl)acetyl) amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo

7-((Carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-(3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Latamoxef

lamoxactam

(R)-Moxalactam

5-oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((carboxy(4-hydroxyphen

Listeria MOX Supplement,Moxalactam

Oxa-cephem

yl)acetyl)amino)-7-methoxy-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo

LMOX