![(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[A,D]环庚烯-10-醇结构式](https://www.chemsrc.com/caspic/132/64520-05-4.png)
(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[A,D]环庚烯-10-醇结构式
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常用名 | (±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[A,D]环庚烯-10-醇 | 英文名 | amitriptyline metabolite (+/-)- |
|---|---|---|---|---|
| CAS号 | 64520-05-4 | 分子量 | 293.40300 | |
| 密度 | 1.151g/cm3 | 沸点 | 453.3ºC at 760mmHg | |
| 分子式 | C20H23NO | 熔点 | 97-99 °C | |
| MSDS | 美版 | 闪点 | 225.4ºC |
| 中文名 | (±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇 |
|---|---|
| 英文名 | (11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol |
| 英文别名 | 更多 |
| 密度 | 1.151g/cm3 |
|---|---|
| 沸点 | 453.3ºC at 760mmHg |
| 熔点 | 97-99 °C |
| 分子式 | C20H23NO |
| 分子量 | 293.40300 |
| 闪点 | 225.4ºC |
| 精确质量 | 293.17800 |
| PSA | 23.47000 |
| LogP | 3.65950 |
| 外观性状 | solid | white |
| 折射率 | 1.651 |
| 水溶解性 | 0.1 M HCl: soluble |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 安全声明 (欧洲) | 22-24/25 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
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~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340 |
|
~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340 |
|
~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340 |
|
~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340 |
|
~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Olesen, Ole V.; Linnet, Kristian Pharmacology, 1997 , vol. 55, # 5 p. 235 - 243 |
|
~%
(±)-E-5-[3-(二甲氨... 64520-05-4 |
| 文献：Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929 |
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Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Clin. Pharmacol. Ther. 52(4) , 350-8, (1992) In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450II... |
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Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.
Drug Metab. Dispos. 9(6) , 565-8, (1981) The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liqui... |
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CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.
Forensic Sci. Int. 158(2-3) , 177-83, (2006) In a series of 202 postmortem toxicology cases, the CYP2D6 and CYP2C19 genes were genotyped, and the concentrations of amitriptyline (AT) and six metabolites were analyzed. The polymorphic CYP2D6 and ... |
| 5H-Dibenzo(a,d)cyclohepten-10-ol,5-(3-(dimethylamino)propylidene)-10,11-dihydro-,(E) |
| ( inverted exclamation markA)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol |
| Amitriptyline metabolite,( inverted exclamation markA)-E-10-hydroxylated |
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