mycaminosyltylonolide

• 常用名: mycaminosyltylonolide
• 英文名: mycaminosyltylonolide
• CAS号: 61257-02-1
• 分子量: 597.73700
• 密度: 1.2g/cm3
• 沸点: 799.9ºC at 760 mmHg
• 分子式: C₃₁H₅₁NO₁₀
• 熔点: N/A
• 闪点: 437.6ºC

mycaminosyltylonolide用途

Mycaminosytylonide是一种强效抗生素。Mycaminosytylonlide显示出抗菌活性。Mycaminosytylonolide抑制荧光素酶合成[1][2]。

mycaminosyltylonolide名称

• 英文名: 5-O-mycaminosyltylonolide

mycaminosyltylonolide生物活性

• 描述: Mycaminosytylonide是一种强效抗生素。Mycaminosytylonlide显示出抗菌活性。Mycaminosytylonolide抑制荧光素酶合成[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 密卡蜜酰尼龙(3µM)抑制 大肠杆菌S30中的萤火虫荧光素酶 mRNA表达翻译[1]。 蜜葡糖基尼龙内酯(0-128µg/mL)具有抗菌活性,对 金葡菌FDA209Pa、金葡菌Smitha、金葡杆菌KUB857c、表皮葡萄球菌KUB795g、粪大肠杆菌ATCC29212h、肺炎克雷伯菌NCTC9632h的 麦克风值分别为 1、 1、2、2、1、64µg/mL[2]
• 参考文献:

  [1]. Shishkina A, et al. Conjugates of amino acids and peptides with 5-o-mycaminosyltylonolide and their interaction with the ribosomal exit tunnel. Bioconjug Chem. 2013 Nov 20;24(11):1861-9.

  [2]. Sugawara A, et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J Antibiot (Tokyo). 2017 Jul;70(8):878-887.

mycaminosyltylonolide物理化学性质

• 密度: 1.2g/cm3
• 沸点: 799.9ºC at 760 mmHg
• 分子式: C₃₁H₅₁NO₁₀
• 分子量: 597.73700
• 闪点: 437.6ºC
• 精确质量: 597.35100
• PSA: 163.06000
• LogP: 1.40240
• 折射率: 1.545

mycaminosyltylonolide英文别名

• 5-O-mycaminosyltylonolid
• O-mycaminosyltylonolide
• Mycaminosyltylonolide
• 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde