Taurolithocholic Acid sodium salt

更新时间：2025-08-25 17:07:38

Taurolithocholic Acid sodium salt结构式	常用名	Taurolithocholic Acid sodium salt	英文名	TAUROLITHOCHOLIC ACID SODIUM SALT
	CAS号	6042-32-6	分子量	505.68600
	密度	N/A	沸点	N/A
	分子式	C₂₆H₄₄NNaO₅S	熔点	N/A
	MSDS	中文版美版	闪点	N/A

Taurolithocholic Acid sodium salt用途

牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。

中文名	牛磺石胆酸钠盐
英文名	taurolithocholic acid sodium salt
中文别名	牛磺石胆酸钠(进分) \| 牛磺石胆酸钠
英文别名	更多

描述	牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。
相关类别	信号通路 >> 跨膜转运 >> 钙通道研究领域 >> 代谢疾病
体外研究	低浓度(5µM)的牛磺胆酸(TLCA)倾向于选择性地将PKC e-亚型的膜相关部分增加44.1%±40.2%[1]。TLCA(10µM)选择性诱导PKCε-亚型移位到肝细胞膜,这是激活可移动PKC亚型的关键步骤[1]。
体内研究	牛磺胆酸(TLCA)通过PI3K依赖机制在灌流大鼠肝脏和大鼠肝细胞偶联物中发挥胆汁抑制作用[2]。
参考文献	[1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82. [2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8.

分子式	C₂₆H₄₄NNaO₅S
分子量	505.68600
精确质量	505.28400
PSA	114.91000
LogP	5.55560
InChIKey	YWXCPBUMOMIAJB-HRHHVWJRSA-N
SMILES	CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C.[Na]
储存条件	-20°C，密闭，干燥

Taurolithocholic Acid sodium saltMSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

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