CP-640186

• 常用名: CP-640186
• 英文名: CP-640186
• CAS号: 591778-68-6
• 分子量: 485.617
• 密度: 1.2±0.1 g/cm3
• 沸点: 721.1±60.0 °C at 760 mmHg
• 分子式: C₃₀H₃₅N₃O₃
• 熔点: N/A
• 闪点: 389.9±32.9 °C

CP-640186用途

CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。

CP-640186名称

• 中文名: CP-640186
• 英文名: [(3R)-1-[1-(anthracene-9-carbonyl)piperidin-4-yl]piperidin-3-yl]-morpholin-4-ylmethanone

CP-640186生物活性

• 描述: CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 乙酰辅酶A羧化酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

  [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.

CP-640186物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 721.1±60.0 °C at 760 mmHg
• 分子式: C₃₀H₃₅N₃O₃
• 分子量: 485.617
• 闪点: 389.9±32.9 °C
• 精确质量: 485.267853
• PSA: 53.09000
• LogP: 3.49
• InChIKey: LDQKDRLEMKIYMC-XMMPIXPASA-N
• SMILES: O=C(c1c2ccccc2cc2ccccc12)N1CCC(N2CCCC(C(=O)N3CCOCC3)C2)CC1
• 外观性状: 浅黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.654
• 储存条件: -20℃

CP-640186英文别名

• Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-
• 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
• 1w2x
• UNII-04L1E4J3ZT
• RCP
• CP 640186
• CP-640186