碘克沙酸

更新时间：2025-08-25 17:05:51

碘克沙酸结构式	常用名	碘克沙酸	英文名	ioxaglic acid
	CAS号	59017-64-0	分子量	1268.88000
	密度	2.545g/cm3	沸点	887.9ºC at 760 mmHg
	分子式	C₂₄H₂₁I₆N₅O₈	熔点	302°C
	MSDS	N/A	闪点	490.8ºC

碘克沙酸用途

Ioxaglic acid(P-286)是带负电的造影剂,可用作计算机断层扫描(CT)中使用的糖胺聚糖(GAG)的反向指示剂。通过定量评估糖胺聚糖含量[1][2],Ioxaglic可用于人类骨关节炎软骨的成像。

中文名	碘克沙酸
英文名	ioxaglic acid
英文别名	更多

描述	Ioxaglic acid(P-286)是带负电的造影剂,可用作计算机断层扫描(CT)中使用的糖胺聚糖(GAG)的反向指示剂。通过定量评估糖胺聚糖含量[1][2],Ioxaglic可用于人类骨关节炎软骨的成像。
相关类别	研究领域 >> 其他信号通路 >> 其他 >> 其他
体内研究	Ioxaglic酸对软骨中观察到的GAG梯度敏感,并且能够测量类似的GAG浓度[2]。
参考文献	[1]. Gonsette RE, et, al. New contrast media in cerebral angiography: animal experiments and preliminary clinical studies. Invest Radiol. Nov-Dec 1980;15(6 Suppl):S270-4. [2]. Baer K, et, al. Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioeng. 2021 Apr 1;5(2):026101.

密度	2.545g/cm3
沸点	887.9ºC at 760 mmHg
熔点	302°C
分子式	C₂₄H₂₁I₆N₅O₈
分子量	1268.88000
闪点	490.8ºC
精确质量	1268.57000
PSA	194.24000
LogP	4.69100
折射率	1.786
水溶解性	Very slightly soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.

碘克沙酸毒性英文版

危险品运输编码	NONH for all modes of transport

Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage.

Osteoarthr. Cartil. 19(10) , 1190-8, (2011)

The effect of threose-induced collagen cross-linking on the mechanical and diffusive properties of cartilage was investigated in vitro. In particular, we investigated the potential of Contrast Enhance...

Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death.

J. Biomech. 45(3) , 497-503, (2012)

In clinical arthrographic examination, strong hypertonic contrast agents are injected directly into the joint space. This may reduce the stiffness of articular cartilage, which is further hypothesized...

Acute thyrotoxicosis secondary to destructive thyroiditis associated with cardiac catheterization contrast dye.

Thyroid 21(4) , 443-9, (2011)

Thyrotoxicosis caused by destructive thyroiditis is self-limited and results from the subacute release of preformed thyroid hormone. Common etiologies include painful subacute thyroiditis and silent (...

Ioxaglic acid

3-[[2-[[3-[acetyl(methyl)amino]-2,4,6-triiodo-5-(methylcarbamoyl)benzoyl]amino]acetyl]amino]-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid