Sorafenib N-Oxide结构式
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常用名 | Sorafenib N-Oxide | 英文名 | Sorafenib N-Oxide |
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CAS号 | 583840-03-3 | 分子量 | 483.84300 | |
密度 | 1.455g/cm3 | 沸点 | 591.655ºC at 760 mmHg | |
分子式 | C21H13ClD3F3N4O4 | 熔点 | 220-222ºC | |
MSDS | N/A | 闪点 | 311.622ºC |
Sorafenib N-Oxide用途Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4. |
英文名 | Sorafenib N-Oxide |
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英文别名 | 更多 |
密度 | 1.455g/cm3 |
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沸点 | 591.655ºC at 760 mmHg |
熔点 | 220-222ºC |
分子式 | C21H13ClD3F3N4O4 |
分子量 | 483.84300 |
闪点 | 311.622ºC |
精确质量 | 483.10000 |
PSA | 104.92000 |
LogP | 6.12010 |
折射率 | 1.601 |
~55% Sorafenib N-Oxide 583840-03-3 |
文献:BAYER CORPORATION Patent: US2003/216446 A1, 2003 ; US 20030216446 A1 |
Sorafenib N-Oxide上游产品 1 | |
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Sorafenib N-Oxide下游产品 0 |
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-1-oxidopyridin-1-ium-2-carboxamide |