萘普生杂质A结构式
|
常用名 | 萘普生杂质A | 英文名 | O-Desmethylnaproxen |
|---|---|---|---|---|
| CAS号 | 52079-10-4 | 分子量 | 216.23300 | |
| 密度 | N/A | 沸点 | 444.1ºC at 760mmHg | |
| 分子式 | C13H12O3 | 熔点 | 182-183ºC | |
| MSDS | 中文版 美版 | 闪点 | 236.5ºC | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
| 中文名 | (S)-2-(6-羟基-2-萘)丙酸 |
|---|---|
| 英文名 | O-Desmethylnaproxen |
| 中文别名 | 甲氧萘丙酸杂质A |
| 英文别名 | 更多 |
| 沸点 | 444.1ºC at 760mmHg |
|---|---|
| 熔点 | 182-183ºC |
| 分子式 | C13H12O3 |
| 分子量 | 216.23300 |
| 闪点 | 236.5ºC |
| 精确质量 | 216.07900 |
| PSA | 57.53000 |
| LogP | 2.73350 |
| 外观性状 | white |
| 储存条件 | 2-8°C |
| 符号 |
GHS07, GHS09 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H317-H400 |
| 警示性声明 | P273-P280 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| 危害码 (欧洲) | Xn,N |
| 风险声明 (欧洲) | 22-43-50/53 |
| 安全声明 (欧洲) | 36/37-60-61 |
| 危险品运输编码 | UN 3077 9/PG 3 |
| WGK德国 | 3 |
| 海关编码 | 2918199090 |
|
~98%
萘普生杂质A 52079-10-4 |
| 文献：Auspex Pharmaceuticals, Inc. Patent: US2007/276042 A1, 2007 ; Location in patent: Page/Page column 58 ; US 20070276042 A1 |
|
~83%
萘普生杂质A 52079-10-4 |
| 文献：BEZWADA BIOMEDICAL, LLC. Patent: US2010/209469 A1, 2010 ; |
|
~95%
萘普生杂质A 52079-10-4 |
| 文献：Ferrayoli, Carlos G.; Palacios, Sara M.; Alonso, Ruben A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 12 p. 1635 - 1638 |
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~%
萘普生杂质A 52079-10-4 |
| 文献：Harrison; Lewis; Nelson; Rooks; Roszkowski; Tomolonis; Fried Journal of medicinal chemistry, 1970 , vol. 13, # 2 p. 203 - 205 |
| 萘普生杂质A上游产品 3 | |
|---|---|
| 萘普生杂质A下游产品 2 | |
| 海关编码 | 2918199090 |
|---|---|
| 中文概述 | HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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The pharmacokinetic profile of naproxen suppository in man.
Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988) After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.... |
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Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.
Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005) Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o... |
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High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.
J. Chromatogr. A. 383(2) , 449-55, (1986)
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| (2S)-2-(6-hydroxynaphthalen-2-yl)propanoic acid |
CAS号26159-35-3