瑞美松龙

• 常用名: 瑞美松龙
• 英文名: Rimexolone
• CAS号: 49697-38-3
• 分子量: 370.525
• 密度: 1.1±0.1 g/cm3
• 沸点: 507.0±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₄O₃
• 熔点: 258-268ºC
• 闪点: 274.5±26.6 °C

瑞美松龙用途

利美索酮(Org 6216)是一种具有抗炎活性的糖皮质激素类固醇。利美索酮可用作1%眼用混悬液,用于治疗眼部炎症[1][2]。

瑞美松龙名称

• 中文名: 瑞美松龙
• 英文名: Rimexolone

瑞美松龙生物活性

• 描述: 利美索酮(Org 6216)是一种具有抗炎活性的糖皮质激素类固醇。利美索酮可用作1%眼用混悬液,用于治疗眼部炎症[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 利美索酮(Org 6216)在注射部位显示出高度增强的持久性,最小的系统效应,几乎不会诱发皮肤营养不良[1]。
• 体内研究: 利美索酮(Org 6216)(0-450μg/只小鼠；关节内注射；一次)在单关节抗原诱导的关节炎小鼠中显示出延长的抗炎作用[1]。动物模型：雄性,8-12周龄C57Black/6小鼠,具有抗原诱导的关节炎[1]剂量：5、25、50、150、250、450μg/小鼠给药：关节内注射,一次结果：以剂量依赖性方式抑制关节炎。在450和150μ。导致软骨细胞蛋白多糖合成的抑制减少。
• 参考文献:

  [1]. Joosten LA, et al. Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide. Agents Actions. 1990 Aug;31(1-2):135-42.

  [2]. Foster CS, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug;122(2):171-82.

瑞美松龙物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 507.0±50.0 °C at 760 mmHg
• 熔点: 258-268ºC
• 分子式: C₂₄H₃₄O₃
• 分子量: 370.525
• 闪点: 274.5±26.6 °C
• 精确质量: 370.250793
• PSA: 54.37000
• LogP: 4.01
• InChIKey: QTTRZHGPGKRAFB-OOKHYKNYSA-N
• SMILES: CCC(=O)C1(C)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC21C
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.559
• 储存条件: 室温

瑞美松龙英文别名

• Rimexolone
• (11β,16α,17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
• 11β-Hydroxy-16α,17α-dimethyl-17-propionylandrosta-1,4-dien-3-one
• 11b-Hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one
• (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on
• (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
• Asoprisnil ecamate
• Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11β,16α,17β)-
• (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tétraméthyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one
• 11β-Hydroxy-16α,17,21-trimethyl-1,4-pregnadien-3,20-dion
• (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
• (8S,9S,10R,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
• VEXOL