3,3'-二碘甲腺原氨酸

更新时间：2024-01-08 15:08:49

3,3'-二碘甲腺原氨酸结构式	常用名	3,3'-二碘甲腺原氨酸	英文名	3,3'-diiodo-L-thyronine
	CAS号	4604-41-5	分子量	525.077
	密度	2.1±0.1 g/cm3	沸点	520.7±50.0 °C at 760 mmHg
	分子式	C₁₅H₁₃I₂NO₄	熔点	178-180ºC
	MSDS	美版	闪点	268.7±30.1 °C
	符号	GHS07	信号词	Warning

3,3'-二碘甲腺原氨酸用途

3,3'-Diiodo-L-thyronine (3,3'-T2) 是一种甲状腺激素的内源性代谢产物 (endogenous metabolite)。3,3'-Diiodo-L-thyronine 显着增强 COX 活性。

中文名	3,3'-二碘甲腺原氨酸
英文名	3,3'-diiodo-L-thyronine
中文别名	O-(对羟基苯基)-3,3'-二碘-L-酪氨酸 \| 3,3'-二碘甲状腺原氨酸 \| O-(对羟基苯基)-3,3'-二碘-L-酪氨酸 \| O-(4-羟基-3-碘苯基)-3-碘-L-酪氨酸 \| (2S)-2-氨基-3-[4-(4-羟基-3-碘苯氧基)-3-碘苯基]丙酸 \| L-3,3'-二碘甲腺原氨酸
英文别名	更多

描述	3,3'-Diiodo-L-thyronine (3,3'-T2) 是一种甲状腺激素的内源性代谢产物 (endogenous metabolite)。3,3'-Diiodo-L-thyronine 显着增强 COX 活性。
相关类别	信号通路 >> 免疫及炎症 >> COX 研究领域 >> 代谢疾病
靶点	Human Endogenous Metabolite COX
体外研究	3,3'-二碘-L-甲状腺素(3,3'-T2；1μM；30min)显著增强COX活性[2]。1μM的3,3'-二碘-L-甲状腺素的影响最大[2]。3,3'-二碘-L-甲状腺素通过进一步降解T3和rT3产生[3]。
参考文献	[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88. [2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94. [3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

密度	2.1±0.1 g/cm3
沸点	520.7±50.0 °C at 760 mmHg
熔点	178-180ºC
分子式	C₁₅H₁₃I₂NO₄
分子量	525.077
闪点	268.7±30.1 °C
精确质量	524.893372
PSA	92.78000
LogP	4.55
蒸汽压	0.0±1.4 mmHg at 25°C
折射率	1.726
储存条件	Amber Vial, -20°C Freezer, Under Inert Atmosphere

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

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3,3’-Diiodo-L-thyronine

O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

3,3'-Diiodo-L-thyronine

L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-

EINECS 225-005-7