3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one

更新时间:2024-01-10 18:15:24

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式
3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式
委托求购
常用名 3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one 英文名 3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one
CAS号 4546-73-0 分子量 268.23
密度 2.29g/cm3 沸点 521.7ºC at 760 mmHg
分子式 C9H12N6O4 熔点 N/A
MSDS N/A 闪点 269.3ºC

 用途


8-氮杂-2’-脱氧鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

 名称

英文名 5-amino-3-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2H-triazolo[4,5-d]pyrimidin-7-one
英文别名 更多

 生物活性

描述 8-氮杂-2’-脱氧鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别
参考文献

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 物理化学性质

密度 2.29g/cm3
沸点 521.7ºC at 760 mmHg
分子式 C9H12N6O4
分子量 268.23
闪点 269.3ºC
精确质量 268.09200
PSA 152.17000
折射率 2

 合成线路

~97%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Seela; Lampe Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2388 - 2397

~56%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Seela; Lampe Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2388 - 2397

~58%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Stepchenko, Vladimir A.; Seela, Frank; Esipov, Roman S.; Miroshnikov, Anatoly I.; Sokolov, Yuri A.; Mikhailopulo, Igor A. Synlett, 2012 , vol. 23, # 10 art. no. ST-2012-B0090-L, p. 1541 - 1545

~%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Seela; Lampe Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2388 - 2397

~%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Seela; Lampe Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2388 - 2397

~23%

3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one结构式

3-amino-9-[4-hy...

4546-73-0

文献:Stepchenko, Vladimir A.; Seela, Frank; Esipov, Roman S.; Miroshnikov, Anatoly I.; Sokolov, Yuri A.; Mikhailopulo, Igor A. Synlett, 2012 , vol. 23, # 10 art. no. ST-2012-B0090-L, p. 1541 - 1545

 英文别名

5-amino-3-(2-deoxypentofuranosyl)-2,3-dihydro-7h-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
8-aza-2'-deoxy-guanosine