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ACTH(4-10)(人类)

更新时间:2024-01-02 21:08:58

ACTH(4-10)(人类)结构式
ACTH(4-10)(人类)结构式
品牌特惠专场
常用名 ACTH(4-10)(人类) 英文名 ACTH (4-10)
CAS号 4037-01-8 分子量 962.09
密度 1.48g/cm3 沸点 N/A
分子式 C44H59N13O10S 熔点 N/A
MSDS 美版 闪点 N/A

 ACTH(4-10)(人类)用途


Adrenocorticotropic Hormone (ACTH) (1-39), rat 是一种有效的黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。

 ACTH(4-10)(人类)名称

中文名 促肾上腺皮质激素(ACTH)(4-10),人
英文名 met-glu-his-phe-arg-trp-gly
英文别名 更多

 ACTH(4-10)(人类)生物活性

描述 Adrenocorticotropic Hormone (ACTH) (1-39), rat 是一种有效的黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。
相关类别
靶点

Melanocortin 4 receptor[1]

体外研究 促肾上腺皮质激素(ACTH)(4-10),人(ACTH(4-10))是所有黑皮质素的核心序列,并选择性地与MC4-R结合。在人类中,ACTH(4-10)在鼻内应用后进入脑液室,并在连续治疗6周后导致总体脂肪减少[1]。
参考文献

[1]. Wellhöner P, et al. Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Int J Obes (Lond). 2012 May;36(5):703-8.

 ACTH(4-10)(人类)物理化学性质

密度 1.48g/cm3
分子式 C44H59N13O10S
分子量 962.09
PSA 183.70000
LogP 9.43540
蒸汽压 4.64E-09mmHg at 25°C
折射率 1.547
储存条件 -20°C,密闭,干燥

 ACTH(4-10)(人类)安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3

 ACTH(4-10)(人类)文献30

更多文献
Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I).

Biochem. Biophys. Res. Commun. 290 , 844-850, (2002)

The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin r...

Sniffing neuropeptides: a transnasal approach to the human brain.

Nat. Neurosci. 5(6) , 514-6, (2002)

The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.

J. Clin. Endocrinol. Metab. 86(3) , 1144-8, (2001)

The control of body fat is a prominent factor in human health. Animal studies have indicated a homeostatic central nervous system regulation of body fat with particular involvement of the melanocortin...

 ACTH(4-10)(人类)英文别名

Adrenalonium chloratum
adrenalon hydrochloride
Adrenone hydrochloride
ADRENALONE,HYDROCHLORIDE
Stryphnonasal
Kephrine hydrochloride
Epinephrine ketone hydrochloride
ADRENALONE HCL
Adrenocorticotropic Hormone (ACTH) (4-10), human