2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-b]吲哚

• 常用名: 2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-b]吲哚
• 英文名: Latrepirdine
• CAS号: 3613-73-8
• 分子量: 319.443
• 密度: 1.1±0.1 g/cm3
• 沸点: 505.7±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₅N₃
• 熔点: 115-116 °C
• 闪点: 259.7±30.1 °C

用途

Latrepirdine is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s and Huntington’s disease. In addition to reported activity in preventing the onset and progression of disease by being neuroprotective, dimebolin appears to promote clinical improvement by increasing cognitive function. At the cellular level, dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels,5 inhibiting NMDA-type glutamate receptors, and preventing mitochondrial leakage.

名称

• 中文名: 2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-b]吲哚
• 英文名: 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
• 中文别名: 2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-B]吲哚 | 丹吡芙蓉

物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 505.7±50.0 °C at 760 mmHg
• 熔点: 115-116 °C
• 分子式: C₂₁H₂₅N₃
• 分子量: 319.443
• 闪点: 259.7±30.1 °C
• 精确质量: 319.204834
• PSA: 21.06000
• LogP: 3.96
• 外观性状: 棕褐色固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.629
• 储存条件: 室温

毒性和生态

安全信息

• 危害码 (欧洲): Xi

英文别名

• 9-(2-(2-Methyl-5-pyridyl)ethyl)-3,6-dimethyl-1,2,3,4-tetrahydro-γ-carboline
• 2,8-Dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• Dimebolin
• Dimebon
• 1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-
• aka latrepiridine
• Dimebone
• Latrepirdine
• Dimeboline
• 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• 2,8-Dimethyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• Preparation 84