(Des-Asp187)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)

• 常用名: (Des-Asp187)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
• 英文名: (Des-Asp187)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
• CAS号: 319927-23-6
• 分子量: 890.03400
• 密度: 1.4±0.1 g/cm3
• 沸点: 1071.5±75.0 °C at 760 mmHg
• 分子式: C₄₂H₆₇N₉O₁₂
• 熔点: N/A
• 闪点: 601.8±37.1 °C

用途

Gp100:209-217是由HLA-A2呈递的Gp100衍生的人CTL表位。Gp100:209-217是含有8个氨基酸的多肽。Gp100:209-217是一种有效的TGF-β抑制剂,阻断TGF-β信号通路[1]。

名称

• 英文名: N-[(2S)-2-{[(2S)-2-({[(2S)-1-{N-[(2S)-2-{[(2S,3R)-2-{[(2S,3S)-2-Amino-1-hydroxy-3-methylpentylidene]amino}-1,3-dihydroxybutylidene]amino}-1,5-dihydroxy-5-iminopentylidene]-L-valyl}-2-pyrrolidinyl](hydroxy)methylene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1,3-dihydroxypropylidene]-L-valine

生物活性

• 描述: Gp100:209-217是由HLA-A2呈递的Gp100衍生的人CTL表位。Gp100:209-217是含有8个氨基酸的多肽。Gp100:209-217是一种有效的TGF-β抑制剂,阻断TGF-β信号通路[1]。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Terabe M, et, al. Synergistic effect of TGF-β blockade and immunogenic agents on tumors. WO2006089251.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 1071.5±75.0 °C at 760 mmHg
• 分子式: C₄₂H₆₇N₉O₁₂
• 分子量: 890.03400
• 闪点: 601.8±37.1 °C
• 精确质量: 889.49100
• PSA: 341.78000
• LogP: 5.99
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.621

英文别名

• N-[(2S)-2-{[(2S)-2-({[(2S)-1-{N-[(2S)-2-{[(2S,3R)-2-{[(2S,3S)-2-Amino-1-hydroxy-3-methylpentylidene]amino}-1,3-dihydroxybutylidene]amino}-1,5-dihydroxy-5-iminopentylidene]-L-valyl}-2-pyrrolidinyl](hydroxy)methylene}amino)-1-hydroxy-3-phenylpropylidene]amino}-1,3-dihydroxypropylidene]-L-valine
• L-Valine, N-[(2S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-amino-1-hydroxy-3-methylpentylidene]amino]-1,3-dihydroxybutylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]hydroxymethylene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1,3-dihydroxypropylidene]-
• (Des-Asp187)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)