盐酸呋咯地辛

• 常用名: 盐酸呋咯地辛
• 英文名: Forodesine (hydrochloride)
• CAS号: 284490-13-7
• 分子量: 302.71400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₅ClN₄O₄
• 熔点: N/A
• 闪点: N/A

盐酸呋咯地辛用途

Forodesine(BCX-1777 freebase; Immucillin-H)盐酸盐是口服活性嘌呤核苷磷酸化酶(PNP)抑制剂，能诱导细胞凋亡，特别是在T淋巴细胞中。

盐酸呋咯地辛名称

• 中文名: 盐酸呋咯地辛
• 英文名: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one,hydrochloride

盐酸呋咯地辛生物活性

• 描述: Forodesine hydrochloride是有效,可口服的嘌呤核苷磷酸化酶 PNP 抑制剂,其中IC50 范围为0.48至1.57 nM。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 癌症
• 参考文献:

  [1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90.

  [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5.

  [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.

  [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.

盐酸呋咯地辛物理化学性质

• 分子式: C₁₁H₁₅ClN₄O₄
• 分子量: 302.71400
• 精确质量: 302.07800
• PSA: 134.52000
• 储存条件: 2-8℃

盐酸呋咯地辛英文别名

• Forodesine hydrochloride
• Forodesine HCl
• UNII-6SN82Y9U73
• 4H-Pyrrolo(3,2-d)pyrimidin-4-one,7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl)-1,5-dihydro-,monohydrochloride
• BCX-1777
• Forodesine hydrochloride (JAN/USAN)
• Forodesine (hydrochloride)