2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚

• 常用名: 2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚
• 英文名: WHI-P97
• CAS号: 211555-05-4
• 分子量: 455.10100
• 密度: 1.785
• 沸点: N/A
• 分子式: C₁₆H₁₃Br₂N₃O₃
• 熔点: N/A
• 闪点: N/A

用途

WHI-P97是JAK-3抑制剂。

名称

• 中文名: 2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚
• 英文名: 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

生物活性

• 描述: WHI-P97是JAK-3抑制剂。
• 相关类别:
  研究领域 >> 炎症/免疫
• 靶点:

  JAK3:11 μM (IC50)

• 参考文献:

  [1]. Ji KA, Yang MS, Jou I, Shong MH, Joe EH.Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.Glia. 2004 Nov 1;48(2):102-11.

  [2]. Wong WS, Leong KP.Tyrosine kinase inhibitors: a new approach for asthma.Biochim Biophys Acta. 2004 Mar 11;1697(1-2):53-69.

  [3]. Uckun FM, Sudbeck EA, Mao C, Ghosh S, Liu XP, Vassilev AO, Navara CS, Narla RK.Structure-based design of novel anticancer agents.Curr Cancer Drug Targets. 2001 May;1(1):59-71.

  [4]. Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, Uckun FM.Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.Clin Cancer Res. 1999 Jun;5(6):1569-82.

物理化学性质

• 密度: 1.785
• 分子式: C₁₆H₁₃Br₂N₃O₃
• 分子量: 455.10100
• 精确质量: 452.93200
• PSA: 76.50000
• LogP: 4.69420
• InChIKey: YVCXQRVVNQMZEI-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
• 储存条件: -20°C

英文别名

• whi-p97
• hms3265e23