牛蒡子苷

更新时间:2019-02-11 13:42:37

牛蒡子苷结构式
牛蒡子苷
常用名 牛蒡子苷 英文名 Arctiin
CAS号 20362-31-6 分子量 534.552
密度 1.4±0.1 g/cm3 沸点 756.4±60.0 °C at 760 mmHg
分子式 C27H34O11 熔点 N/A
MSDS 中文版 美版 闪点 250.1±26.4 °C

 牛蒡子苷用途


Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。

 牛蒡子苷名称

中文名 牛蒡子苷
英文名 Arctiin
中文别名 牛蒡苷
英文别名 更多

 牛蒡子苷生物活性

描述 Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。
相关类别
溶解度
体外:

DMSO:≥5.4mg / mL(10.10 mM)

* “≥”表示可溶,但饱和度未知。

储备液
1 mM 1.8707 mL 9.3537 mL 18.7073 mL
5 mM 0.3741 mL 1.8707 mL 3.7415 mL
10 mM 0.1871 mL 0.9354 mL 1.8707 mL
存储
粉末 -20℃下 3年
4℃下 2年
在溶剂中 -80℃下 6个月
-20℃下 1个月
运输 室温;可能会有所不同
SMILES O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(OC)C=C(C[C@H]3C(OC[C@@H]3CC4=CC(OC)=C(OC)C=C4)=O)C=C2)[C@@H]1O
参考文献

[1]. Huang DM, et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate. 2004 May 15;59(3):260-7.

[2]. Knipping K, et al. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77.

[3]. Zeng Y, et al. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett. 2005 May 26;222(2):145-51.

[4]. Wu JG, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

[5]. Ma ST, et al. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80.

[6]. Matsuzaki Y, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

相关活性
小分子
磺丁基-β-环糊精 | 环孢菌素 | 2',7'-二氯荧光素二乙酸酯 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | 4',4''-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐 | 乙莫克舍 | TD139 | Mitoquinone甲磺酸盐 | GSK2795039 | JC-1 | 胞内钙荧光探针 BAPTA-AM | AP20187 | GKT137831 | D-荧光素 | 野百合碱
相关文档

SDS |COA |HNMR |LCMS

*以上文档由Medchemexpress提供,仅用于科学研究参考。

 牛蒡子苷物理化学性质

密度 1.4±0.1 g/cm3
沸点 756.4±60.0 °C at 760 mmHg
分子式 C27H34O11
分子量 534.552
闪点 250.1±26.4 °C
精确质量 534.210083
PSA 153.37000
LogP 0.23
外观性状 白色至灰白色固体
蒸汽压 0.0±2.7 mmHg at 25°C
折射率 1.601
储存条件 ?20°C

 牛蒡子苷安全信息

危险品运输编码 NONH for all modes of transport

 牛蒡子苷文献29

更多文献
Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.

Planta Med. 78(8) , 800-6, (2012)

The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV techn...

Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.

Fitoterapia 86 , 6-12, (2013)

Arctiin, an important lignan compound in Fructus Arctii, has been reported to possess various kinds of bioactivities. Previous studies on the pharmacokinetic of arctiin after oral administration showe...

Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats.

Planta Med. 78(12) , 1317-23, (2012)

Diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L., has been reported to have a...

 牛蒡子苷英文别名

MFCD00870630
Arctiin (8CI)
4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydro-3-furanyl]methyl}-2-methoxyphenyl β-D-glucopyranoside
Arctigenin-4-glucoside
Arctin
Arctlin
2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(b-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-
Arctiin
4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydrofuran-3-yl]methyl}-2-methoxyphenyl β-D-glucopyranoside
2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-
Great Burdock Root Extract
NSC 315527
Acrctiin
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参考价格:¥273/10mg

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