1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-

• 常用名: 1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-
• 英文名: NU1085
• CAS号: 188106-83-4
• 分子量: 253.25600
• 密度: 1.426g/cm3
• 沸点: 626.2ºC at 760 mmHg
• 分子式: C₁₄H₁₁N₃O₂
• 熔点: N/A
• 闪点: 332.5ºC

1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-用途

NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h.

1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-名称

• 中文名: 1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-
• 英文名: 2-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3-dihydrobenzimidazole-4-carboxamide

1H-苯并咪唑-7-羧酰胺,2-(4-羟基苯基)-物理化学性质

• 密度: 1.426g/cm3
• 沸点: 626.2ºC at 760 mmHg
• 分子式: C₁₄H₁₁N₃O₂
• 分子量: 253.25600
• 闪点: 332.5ºC
• 精确质量: 253.08500
• PSA: 92.99000
• LogP: 2.91860
• 蒸汽压: 2.83E-16mmHg at 25°C
• 折射率: 1.745