NU1085
Modify Date: 2025-09-12 13:30:40
NU1085 structure
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Common Name | NU1085 | ||
|---|---|---|---|---|
| CAS Number | 188106-83-4 | Molecular Weight | 253.25600 | |
| Density | 1.426g/cm3 | Boiling Point | 626.2ºC at 760 mmHg | |
| Molecular Formula | C14H11N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 332.5ºC | |
Use of NU1085NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h. |
| Name | 2-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3-dihydrobenzimidazole-4-carboxamide |
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| Density | 1.426g/cm3 |
|---|---|
| Boiling Point | 626.2ºC at 760 mmHg |
| Molecular Formula | C14H11N3O2 |
| Molecular Weight | 253.25600 |
| Flash Point | 332.5ºC |
| Exact Mass | 253.08500 |
| PSA | 92.99000 |
| LogP | 2.91860 |
| Vapour Pressure | 2.83E-16mmHg at 25°C |
| Index of Refraction | 1.745 |