(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

• 常用名: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
• 英文名: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
• CAS号: 172721-98-1
• 分子量: 261.31600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₉NO₃
• 熔点: N/A
• 闪点: N/A

用途

红土霉素是酰基辅酶a：胆固醇酰基转移酶(ACAT)的有效抑制剂,从赤霉素IFO 7188的菌丝饼中分离出来[1]。红土霉素还抑制一小部分人类癌细胞系、革兰氏阳性细菌和白色念珠菌的生长[2]。

名称

• 英文名: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

生物活性

• 描述: 红土霉素是酰基辅酶a：胆固醇酰基转移酶(ACAT)的有效抑制剂,从赤霉素IFO 7188的菌丝饼中分离出来[1]。红土霉素还抑制一小部分人类癌细胞系、革兰氏阳性细菌和白色念珠菌的生长[2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
• 靶点:

  IC50: 6 μM (ACAT, acyl-CoA:cholesterol acyltransferase)[1]

• 参考文献:

  [1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7.

  [2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1.

物理化学性质

• 分子式: C₁₅H₁₉NO₃
• 分子量: 261.31600
• 精确质量: 261.13600
• PSA: 46.61000
• LogP: 1.57540

英文别名

• (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione