Kdo2-Lipid A ammonium

• 常用名: Kdo2-Lipid A ammonium
• 英文名: Di[3-deoxy-D-Manno-octulosonyl]-lipid A (amMonium salt)
• CAS号: 1246298-62-3
• 分子量: 2326.646
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁₀H₁₉₈N₂Na₄O₃₉P₂
• 熔点: N/A
• 闪点: N/A

Kdo2-Lipid A ammonium用途

Kdo2脂质A铵是一种化学定义的脂多糖(LPS),其内毒素活性等同于LPS。Kdo2脂质A铵对TLR4具有高度选择性。Kdo2脂质A铵刺激TNF和PGE2的释放[1]。

Kdo2-Lipid A ammonium名称

• 中文名: 二[3-脱氧-D-甘露聚糖-八磺酰基]-脂质A(铵盐)
• 英文名: Tetrasodium 3-deoxy-6-[(1R)-1,2-dihydroxyethyl]hex-2-ulopyranonosyl-(2->4)-3-deoxy-6-[(1R)-1,2-dihydroxyethyl]hex-2-ulopyranonosyl-(2->6)-2-deoxy-2-{[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino}-4-O-(hydroxyphosphinato)-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]hexopyranosyl-(1->6)-2-deoxy-1-O-(hydroxyphosphinato)-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}hexopyranose

Kdo2-Lipid A ammonium生物活性

• 描述: Kdo2脂质A铵是一种化学定义的脂多糖(LPS),其内毒素活性等同于LPS。Kdo2脂质A铵对TLR4具有高度选择性。Kdo2脂质A铵刺激TNF和PGE2的释放[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 其他
• 靶点:

  TLR4

• 体外研究: Kdo2脂质A(1µM)刺激成年大鼠脊髓星形胶质细胞培养物中TNF和PGE2的释放[1]。RT-PCR[1]细胞系：TNF和PGE2浓度：1µM培养时间：结果：TNF和PGE2的蛋白质(mg)含量分别为6.2±0.6 ng/mL和1.4±0.3 ng/mL。
• 体内研究: KDO2脂质A(i.t.)激活大鼠的toll样受体4(TLR4)[1]。动物模型：大鼠(雄性Holzman-Sprague-Dawley,300-400克)[1]剂量：0.1至10微克给药：I.T。；0.1-10微克；结果：鞘内注射1µg Kdo2脂质A可引起痛觉超敏,注射Kdo2脂质A后动物出现疾病。
• 参考文献:

  [1]. Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010;160(7):1754-1764.

Kdo2-Lipid A ammonium物理化学性质

• 分子式: C₁₁₀H₁₉₈N₂Na₄O₃₉P₂
• 分子量: 2326.646
• 精确质量: 2325.263672
• 外观性状: 固体
• 储存条件: 20°C

Kdo2-Lipid A ammonium英文别名

• Tetrasodium 3-deoxy-6-[(1R)-1,2-dihydroxyethyl]hex-2-ulopyranonosyl-(2->4)-3-deoxy-6-[(1R)-1,2-dihydroxyethyl]hex-2-ulopyranonosyl-(2->6)-2-deoxy-2-{[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino}-4-O-(hydroxyphosphinato)-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]hexopyranosyl-(1->6)-2-deoxy-1-O-(hydroxyphosphinato)-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}hexopyranose
• Hexopyranose, O-3-deoxy-D-glycero-2-octulopyranonosyl-(2->4)-O-3-deoxy-D-glycero-2-octulopyranonosyl-(2->6)-O--2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphonohexopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxy-1-oxotetradecyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate), sodium salt (1:4)