rac-Rotigotine Hydrochloride

• 常用名: rac-Rotigotine Hydrochloride
• 英文名: (Rac)-Rotigotine hydrochloride
• CAS号: 102120-99-0
• 分子量: 351.93400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₆ClNOS
• 熔点: N/A
• 闪点: N/A

rac-Rotigotine Hydrochloride用途

rac-Rotigotine盐酸盐是D-2受体选择性激动剂,Ki为0.69 nM。

rac-Rotigotine Hydrochloride名称

• 中文名: 5,6,7,8-四氢-6-[丙基[2-(3-噻吩基)乙基]氨基]-1-羟基萘盐酸盐
• 英文名: rac-Rotigotine Hydrochloride

rac-Rotigotine Hydrochloride生物活性

• 描述: rac-Rotigotine盐酸盐是D-2受体选择性激动剂,Ki为0.69 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rocchi C, Pierantozzi M, Pisani V, Marfia GA, Di Giorgio A, Stanzione P, Bernardi G, Stefani A.The Impact of Rotigotine on Cardiovascular Autonomic Function in Early Parkinson's Disease.Eur Neurol. 2012 Aug 28;68(3):187-192.

  [2]. Wang A, Wang L, Sun K, Liu W, Sha C, Li Y.Preparation of Rotigotine-Loaded Microspheres and Their Combination Use with L-DOPA to Modify Dyskinesias in 6-OHDA-Lesioned Rats.Pharm Res. 2012 Sep;29(9):2367-76.

  [3]. Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.disord. 9 147.

  [4]. Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73.

  [5]. Oertel W, Lewitt P, Giladi N, Ghys L, Grieger F, Boroojerdi B.Treatment of patients with early and advanced Parkinson's disease with rotigotine transdermal system: Age-relationship to safety and tolerability.Parkinsonism Relat Disord. 2012 Sep 3.

rac-Rotigotine Hydrochloride物理化学性质

• 分子式: C₁₉H₂₆ClNOS
• 分子量: 351.93400
• 精确质量: 351.14200
• PSA: 51.71000
• LogP: 5.06770
• InChIKey: CEXBONHIOKGWNU-UHFFFAOYSA-N
• SMILES: CCCN(CCc1cccs1)C1CCc2c(O)cccc2C1.Cl
• 储存条件: 2-8℃

rac-Rotigotine Hydrochloride安全信息

• 海关编码: 2934999090

rac-Rotigotine Hydrochloride海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

rac-Rotigotine Hydrochloride英文别名

• rac-Rotigotine (Hydrochloride)