77094-11-2

• 常用中文名：2-氨基-3,4-二甲基-3H-咪唑并喹啉
• 常用英文名：MeIQ
• CAS号：77094-11-2
• 分子式：C₁₂H₁₂N₄
• 分子量：212.25000
• 相关类别： 研究领域 癌症
• 发布时间：2018-12-24 13:18:36
• 更新时间：2025-08-25 17:24:56
• Me IQ(甲基IQ)是一种口服活性杂环胺,具有致癌和致突变作用。Me IQ在肝脏中的致突变性是未诱导小鼠和兔子的肺微粒体制剂的几百倍[1][2]。

名称

• 中文名: 2-氨基-3,4-二甲基-3H-咪唑并喹啉
• 英文名: 3,4-dimethylimidazo[4,5-f]quinolin-2-amine
• 中文别名: 2-氨基-3,4-二甲基-3H-咪唑并 [4,5-f]喹啉
• 英文别名: Methyl IQ; Me IQ; 3,4-dimethyl-3H-imidazo<quinolin-2-amine; MelQ; 2-amino-3,4-dimethylimidazo<4,5-f>quinoline

物化性质

• 密度: 1.36g/cm3
• 沸点: 465.7ºC at 760 mmHg
• 熔点: 291-293ºC
• 分子式: C₁₂H₁₂N₄
• 分子量: 212.25000
• 闪点: 235.4ºC
• 精确质量: 212.10600
• PSA: 56.73000
• LogP: 2.59330
• 折射率: 1.725
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Me IQ(甲基IQ)是一种口服活性杂环胺,具有致癌和致突变作用。Me IQ在肝脏中的致突变性是未诱导小鼠和兔子的肺微粒体制剂的几百倍[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: Me IQ(甲基IQ；含0.04%或0.01%的饮食) 导致小鼠前胃鳞状细胞癌和乳头状瘤的发生率很高。0.04%剂量组的 我的智商诱发的前胃鳞状细胞癌中约40%转移至肝脏[1]。
• 参考文献:

  [1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105.

  [2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5907000 CHEMICAL NAME : 3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl- CAS REGISTRY NUMBER : 77094-11-2 LAST UPDATED : 199807 DATA ITEMS CITED : 30 MOLECULAR FORMULA : C12-H12-N4 MOLECULAR WEIGHT : 212.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5040 mg/kg/40W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7476 mg/kg/89W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22120 mg/kg/81W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27888 mg/kg/83W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : Specific locus test TYPE OF TEST : Morphological transformation TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : Sister chromatid exchange MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - guinea pig Lung DOSE/DURATION : 10 umol/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993

安全

• 危害码 (欧洲): T: Toxic;
• 海关编码: 2933990090

合成路线

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%