316819-28-0

• 常用中文名：甲磺酸加替沙星
• 常用英文名：Gatifloxacin (mesylate)
• CAS号：316819-28-0
• 分子式：C₂₀H₂₆FN₃O₇S
• 分子量：471.500
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-03-04 08:00:00
• 更新时间：2024-01-09 17:26:34
• Gatifloxacin甲磺酸盐是第四代氟喹诺酮类抗生素,能抑制细菌的DNA旋转酶和拓扑异构酶IV。

名称

• 中文名: 甲磺酸加替沙星
• 英文名: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid
• 英文别名: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1); 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, methanesulfonate (1:1); Gatifloxacin mesylate; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate (1:1); Gatifloxacin (mesylate)

物化性质

• 分子式: C₂₀H₂₆FN₃O₇S
• 分子量: 471.500
• 精确质量: 471.147552
• PSA: 146.55000
• LogP: 2.95900
• 储存条件: 2-8℃，干燥

生物活性

• 描述: Gatifloxacin甲磺酸盐是第四代氟喹诺酮类抗生素,能抑制细菌的DNA旋转酶和拓扑异构酶IV。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Fukuda, H., S. Hori, and K. Hiramatsu, Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. A

  [2]. Jensen, H., et al., Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther, 2005. 21(1): p. 36-43.

  [3]. Cheung, O., et al., Gatifloxacin-induced hepatotoxicity and acute pancreatitis. Ann Intern Med, 2004. 140(1): p. 73-4.

  [4]. Fteha, A., et al., Gatifloxacin induced torsades de pointes. Pacing Clin Electrophysiol, 2004. 27(10): p. 1449-50.