65057-90-1

65057-90-1结构式
65057-90-1结构式

化源商城直购

中文名 他利霉素
英文名 Talisomycin
英文别名 Antibiotic BU-2231A
Tallysomycin A
Bu-2231A
密度 1.58g/cm3
分子式 C68H110N22O27S2
分子量 1731.86000
精确质量 1730.74000
PSA 881.89000
折射率 1.686

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC5990300
CHEMICAL NAME :
Bleomycinamide, N(sup 1)-(4-amino-6-((3-((4-aminobutyl)amino)propyl)amino)- 6-oxohexyl)- 13-((4-amino-4,6-dideoxy-alpha-L-talopyranosyl)oxy)-1 9-demethyl-12-hydroxy-
CAS REGISTRY NUMBER :
65057-90-1
LAST UPDATED :
199512
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C68-H110-N22-O27-S2
MOLECULAR WEIGHT :
1732.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis (interstitial)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,288,1983