Bleomycinamide,N1-[4-amino-6-[[3-[(4-aminobutyl)amino]propyl]amino]-6-oxohexyl]-13-[(4-amino-4,6-dideoxy-a-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy-

Modify Date: 2025-08-24 15:53:45

Bleomycinamide,N1-[4-amino-6-[[3-[(4-aminobutyl)amino]propyl]amino]-6-oxohexyl]-13-[(4-amino-4,6-dideoxy-a-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy- structure	Common Name	Bleomycinamide,N1-[4-amino-6-[[3-[(4-aminobutyl)amino]propyl]amino]-6-oxohexyl]-13-[(4-amino-4,6-dideoxy-a-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy-
	CAS Number	65057-90-1	Molecular Weight	1731.86000
	Density	1.58g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₈H₁₁₀N₂₂O₂₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Name	Talisomycin
Synonym	More Synonyms

Density	1.58g/cm3
Molecular Formula	C₆₈H₁₁₀N₂₂O₂₇S₂
Molecular Weight	1731.86000
Exact Mass	1730.74000
PSA	881.89000
Index of Refraction	1.686

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EC5990300

CHEMICAL NAME :: Bleomycinamide, N(sup 1)-(4-amino-6-((3-((4-aminobutyl)amino)propyl)amino)- 6-oxohexyl)- 13-((4-amino-4,6-dideoxy-alpha-L-talopyranosyl)oxy)-1 9-demethyl-12-hydroxy-

CAS REGISTRY NUMBER :: 65057-90-1

LAST UPDATED :: 199512

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C68-H110-N22-O27-S2

MOLECULAR WEIGHT :: 1732.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg/4W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis (interstitial)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,288,1983

Antibiotic BU-2231A

Tallysomycin A

Bu-2231A

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