95-53-4

95-53-4结构式

常用中文名：邻甲苯胺
常用英文名：o-Toluidine
CAS号：95-53-4
分子式：C₇H₉N
分子量：107.153
相关类别：有机原料氨基化合物环烷胺、芳香单胺、芳香多胺及其衍生物和盐
发布时间：2018-07-21 10:30:10
更新时间：2024-01-02 20:40:28
用作染料、农药、医药及有机合成中间体

中文名	邻甲苯胺
英文名	o-toluidine
中文别名	2-甲基苯胺邻甲基苯胺 2-氨基甲苯邻氨基甲苯
英文别名	o-Toluidin 2-methylbenzenamine toluidine ortho-methyl aniline o-Toluidine 2-Methylaniline o-Toluidyna Benzenamine, 2-methyl- 1-amino-2-methylbenzene 2-Toluidine 2-methyl-aniline EINECS 202-429-0 o-Toluide 2-methylphenylamine toluidines 0-Toluidine MFCD00007730

密度	1.0±0.1 g/cm3
沸点	200.4±0.0 °C at 760 mmHg
熔点	-23 °C
分子式	C₇H₉N
分子量	107.153
闪点	85.0±0.0 °C
精确质量	107.073502
PSA	26.02000
LogP	1.40
外观性状	淡黄色至淡琥珀色液体
蒸汽密度	3.7 (vs air)
蒸汽压	0.3±0.3 mmHg at 25°C
折射率	1.568
储存条件	储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装要求密封，不可与空气接触。应与氧化剂、酸类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.化学性质：与苯胺相似。与酸生成盐。与亚硝酸发生重氮化反应，生成重氮化合物。与醇、卤代烃、烯烃等反应，生成N-烷基化合物。在芳核上能发生烷基化、卤化、磺化、硝化、亚硝化等反应，发生在氨基的邻位和对位。与粉末状硫加热到200 ℃生成噻唑环。在稀硫酸中用铬酸、二氧化锰氧化时，根据条件不同，生成对甲苯醌、2,2'-二甲基偶氮苯或邻硝基甲苯等。用锂还原时得到2-甲基环己胺。 2.稳定性稳定 3.禁配物强氧化剂、酸类、酰基氯、酸酐、氯仿 4.避免接触的条件光照、受热 5.聚合危害不聚合 6.分解产物氨
水溶解性	1.5 g/100 mL (25 ºC)
分子结构	1、摩尔折射率：35.31 2、摩尔体积（cm³/mol）：107.9 3、等张比容（90.2K）：270.7 4、表面张力（dyne/cm）：39.5 5、极化率（10-24cm3）：13.99
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:1 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积26 7.重原子数量:8 8.表面电荷:0 9.复杂度:70.8 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色或淡黄色油状液体 2.熔点（℃）：-16.3 3.沸点（℃）：200.3 4.相对密度（水=1）：1.008 5.相对蒸气密度（空气=1）：3.69 6.饱和蒸气压（kPa）：0.0346（25℃） 7.燃烧热（kJ/mol）：-4054.3 8.临界压力（MPa）：3.75 9.辛醇/水分配系数：1.32 10.闪点（℃）：85（CC） 11.引燃温度（℃）：481.67 12.爆炸上限（%）：7.6 13.爆炸下限（%）：1.5 14.溶解性：微溶于水，溶于乙醇、乙醚、稀酸。 15.黏度（mPa·s,15ºC）：5.195 16.黏度（mPa·s,25ºC）：3.390 17.蒸发热（KJ/kg,b.p.）：416.4 18.熔化热（KJ/kg）：70.3 19.生成热（KJ/mol）：-2.76 20.燃烧热（KJ/mol,定压）：4060.9 21.燃烧热（KJ/mol,定容）：4035.2 22.比热容（KJ/(kg·K) ,15~64ºC,定压）：2.05 23.热导率（W/(m·K),液体）：0.1845 24.热导率（W/(m·K),20ºC）：0.1586 25.电导率（S/m,25ºC）：3.792×10^-7

国标编号:	61750
ＣＡＳ:	95-53-4
中文名称:	2-甲基苯胺
英文名称:	2-Toluidine；o-Toluidine
别名:	邻甲苯胺；2-氨基甲苯；邻氨基甲苯
分子式:	C₇H₉N；CH₃C₆H₄NH₂
分子量:	107.15
熔点:	-24.4℃ 沸点：199.7?
密度:	相对密度(水=1)1.00；
蒸汽压:	85℃
溶解性:	微溶于水，溶于乙醇、乙醚、稀酸
稳定性:	稳定
外观与性状:	无色或淡黄色油状液体
危险标记:	14(毒害品)
用途:	用作染料中间体、有机合成及合成糖精等

2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：本品是强烈的高铁血红蛋白形成剂，并能刺激膀胱尿道，能致血尿。
急性中毒：多由皮肤污染而吸收。引起自觉脸部灼热、剧烈头痛、头晕、呼吸困难，呈现紫绀症。以后出现血尿、尿闭、精神障碍、肌肉抽搐。

慢性中毒：可引起膀胱刺激症状。
二、毒理学资料及环境行为
急性毒性：LD ₅₀670mg/kg(大鼠经口)；3250mg/kg(兔经皮)；人吸入176mg/m ³×60分钟，严重毒作用；人吸入44mg/m ³，出现症状；人吸入22mg/m ³，不悦感。
致突变性：微生物致突变性：鼠伤寒沙门氏菌阳性。
致癌性：小鼠经口最低中毒剂量(TDL ₀)：870g/kg(7周，连续)，致肿瘤阳性。大鼠经口最低中毒剂量(TDL ₀)：8200mg/kg(24周，间歇)，致肿瘤阳性。
危险特性：遇明火、高热或与氧化剂接触，有引起燃烧爆炸的危险。受高热分解放出有毒气体。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。

3.现场应急监测方法:

4.实验室监测方法:
对二甲氨基本甲醛比色法《空气中有害物质的测定方法》(第二版)杭士平主编
对硝基重氮苯比色法《空气中有害物质的测定方法》(第二版)杭士平主编
气相色谱法《空气中有害物质的测定方法》(第二版)杭士平主编

5.环境标准:

前苏联	车间卫生标准	3mg/m³
前苏联(1975)	水体中有害物质最高允许浓度	1.0mg/L
	空气中嗅觉阈浓度	1.1ppm

6.应急处理处置方法:
一、泄漏应急处理
疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴好防毒面具，穿化学防护服。戴好防毒面具，穿一般消防防护服。合理通风，不要直接接触泄漏物，在确保安全情况下堵漏。喷雾状水，减少蒸发。用沙土或其它不燃性吸附剂混合吸收，然后收集运至废物处理场所处置。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。
废弃物处置方法：建议用控制焚烧法处置。焚烧炉排出的氮氧化物通过洗涤器或高温装置除去。
二、防护措施
呼吸系统防护：可能接触其蒸气时，佩带防毒面具。紧急事态抢救或逃生时，佩带正压自给式呼吸器。
眼睛防护：戴安全防护眼镜。
防护服：穿紧袖工作服，长统胶鞋。
手防护：戴橡皮手套。
其它：工作现场禁止吸烟、进食和饮水。及时换洗工作服。工作前后不饮酒，用温水洗澡。监测毒物。进行就业前和定期的体检。
三、急救措施
皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。注意手、足和指甲等部位。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。
吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即时进行人工呼吸。就医。
食入：误服者给漱口，饮水，洗胃后口服活性炭，再给以导泻。就医。
灭火方法：雾状水、泡沫、二氧化碳、干粉、砂土。

毒理学数据:

1、急性毒性：大鼠经口LD50：940mg/kg；兔经皮LD50：3250mg/kg。

2、邻甲苯胺生成的高铁血红蛋白，引起神经障碍的作用很强，并能直接刺激膀胱，引起严重的膀胱炎、膀胱出血和血尿。本品能因皮肤吸收而中毒，应避免与皮肤接触。TJ 36—79规定车间空气中最高容许浓度为5mg/m3。

3.急性毒性

LD50：670mg/kg（大鼠经口）；3250ul（3250mg）/kg（兔经皮）

LC50：862ppm（大鼠吸入，4h）

4.刺激性

家兔经皮：500mg（24h），轻度刺激。

家兔经眼：750μg（24h），重度刺激。

5.致突变性微生物致突变性：鼠伤寒沙门菌40μg/皿。微核试验：人淋巴细胞2mmol/L。程序外DNA合成：人HeLa细胞50μL/L。DNA抑制：人HeLa细胞50μL/L。姐妹染色单体交换：人淋巴细胞200μmol/L。哺乳动物体细胞突变：人淋巴细胞450mg/L。

6.致癌性 IARC致癌性评论：G2A，可能人类致癌物。

生态学数据:

1.生态毒性

LC50：100mg/L（96h）（鱼）

EC50：8mg/L（48h）（水蚤）

IC50：0.31~6.3mg/L（72h）（藻类）

2.生物降解性

好氧生物降解（h）：24~168

厌氧生物降解（h）：96~672

3.非生物降解性

光解最大光吸收（nm）：234~284

光解最大光吸收波长范围（nm）：62.4~3480

空气中光氧化半衰期（h）：0.394~3.94

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU2975000

CHEMICAL NAME :: o-Toluidine

CAS REGISTRY NUMBER :: 95-53-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 99

MOLECULAR FORMULA :: C7-H9-N

MOLECULAR WEIGHT :: 107.17

WISWESSER LINE NOTATION :: ZR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 25 mg/m3

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - hematuria Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 862 ppm/4H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3250 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 151 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1125 mg/kg/5D-C

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10200 mg/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 109 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg female 15-21 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - transplacental tumorigenesis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 840 mg/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7250 mg/kg/23W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 9520 mg/kg

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 9520 mg/kg

SEX/DURATION :: female 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 952 mg/kg

SEX/DURATION :: female 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Liver

REFERENCE :: PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,397,1985 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 8.8 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,349,1978 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,155,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,362,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (22 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,261,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (9 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 2 ppm (8.8 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 2 ppm (9 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 2 ppm (9 mg/m3);Carcinogen JAN 1993 OEL-FRANCE;Carcinogen (salts) JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 3 mg/m3 JAN 1993 OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1 mg/m3;Skin;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (9 mg/m3);STEL 5 ppm (22 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-TOLUIDINE-air:CA lowest feasible concentration (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 73470 No. of Facilities: 2912 (estimated) No. of Industries: 21 No. of Occupations: 20 No. of Employees: 13053 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 73470 No. of Facilities: 2517 (estimated) No. of Industries: 32 No. of Occupations: 25 No. of Employees: 30019 (estimated) No. of Female Employees: 15501 (estimated)

符号	GHS06, GHS08, GHS09
信号词	Danger
危害声明	H301-H319-H331-H350-H400
警示性声明	P201-P261-P273-P301 + P310-P305 + P351 + P338-P311
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	T:Toxic;N:Dangerousfortheenvironment;
风险声明 (欧洲)	R23/25;R36;R45;R50
安全声明 (欧洲)	S53-S45-S61-S36/37/39-S26-S36/37-S16-S7
危险品运输编码	UN 2920 8/PG 1
WGK德国	3
RTECS号	XU2975000
包装等级	II
危险类别	6.1
海关编码	29214300

上游产品 10
88-72-2 95-46-5 615-37-2 16419-60-6
95-49-8 821014-19-1 67-56-1 201230-82-2
97-56-3 195062-59-0
下游产品 10
10378-79-7 104330-53-2 106736-05-4 109532-22-1
107027-12-3 10468-64-1 108714-89-2 107622-79-7
75794-20-6 100305-95-1

1.由邻硝基甲苯还原而得。还原反应可利用铁粉作还原剂，也可在铜催化剂存在下于260-280℃进行加氢反应制得邻甲苯胺。工业品邻甲苯胺的含量（总氨基物含量）在99%以上，加氢还原法每吨产品消耗邻硝基甲苯1300kg、氢气940m3。

2.其制备方法是由邻硝基甲苯经催化加氢还原制得。由于加氢催化剂的不同，反应条件各异，如用铜催化剂，反应温度260℃，也可用镍催化剂。

精制方法：按照制造方法不同，含有间甲苯胺、对甲苯胺、硝基甲苯等杂质。特别是对甲苯胺含量较多，并含有微量的水分。精制方法和苯胺类似，但用蒸馏的方法难以将其他的甲苯胺分离。因此首先将粗制邻甲苯胺蒸馏两次，再溶解于四倍体积的乙醚中，加入等当量的草酸乙醚溶液。将生成的对甲苯胺草酸盐过滤除去，滤液蒸去乙醚后滤出生成的邻甲苯胺草酸盐。用含有草酸的水重结晶5次，再用碳酸钠溶液处理。游离出的邻甲苯胺用氯化钙干燥后减压蒸馏三次可得纯品。

3.取邻硝基甲苯在稀酸介质中用铁粉还原，然后分离。上述所得邻甲苯胺粗品加酸溶解成盐，再加氢氧化钠沉淀，即得纯品。

海关编码	2921430020
中文概述	2921430020 邻甲苯胺。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的
Summary	2921430020 o-toluidine。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

95-53-4	119-93-7
120-66-1	151985-13-6
68408-20-8	95-69-2
636-21-5	443-86-7
452-71-1	583-75-5