193979-75-8

• 常用中文名：CB34
• 常用英文名：CB34
• CAS号：193979-75-8
• 分子式：C₂₁H₂₂Cl₃N₃O
• 分子量：438.77800
• 发布时间：2017-11-25 16:38:51
• 更新时间：2024-01-02 19:42:57
• A potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.

名称

• 英文名: 2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide
• 英文别名: N,N-di-n-propyl-[2-(4-chlorophenyl)-6,8-dichloroimidazo[1,2-a]pyridin-3-yl]acetamide; N,N-Dipropyl-2-(4-chlorophenyl)-6,8-dichloro-imidazo[1,2-a]pyridine-3-acetamide; Lopac-C-6862; CB 34; Alpdem

物化性质

• 分子式: C₂₁H₂₂Cl₃N₃O
• 分子量: 438.77800
• 精确质量: 437.08300
• PSA: 37.61000
• LogP: 6.15260

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26
• 危险品运输编码: NONH for all modes of transport

合成路线

53503-49-4 ~% 193979-75-8

文献：Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118

35158-46-4 ~% 193979-75-8

文献：Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118

362512-44-5 ~% 193979-75-8

文献：Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118

193979-50-9 ~% 193979-75-8

文献：Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118

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