7681-49-4

7681-49-4结构式
7681-49-4结构式
  • 常用中文名:氟化钠
  • 常用英文名:Sodium Fluoride
  • CAS号:7681-49-4
  • 分子式:FNa
  • 分子量:41.98820
  • 相关类别: 原料药 专科用药 口腔科用药
  • 发布时间:2018-02-08 08:00:00
  • 更新时间:2024-01-02 21:08:01
  • 氟化钠是氟化的无机盐, 用作杀虫剂, 也可以用来供水, 作为木材防腐剂,在清洗剂,制造玻璃,及其他方面具有多种用途。

化源商城直购

中文名 氟化钠
英文名 sodium fluoride
英文别名 EINECS 231-667-8
MFCD00003524
Sodium fluoride
描述 氟化钠是氟化的无机盐, 用作杀虫剂, 也可以用来供水, 作为木材防腐剂,在清洗剂,制造玻璃,及其他方面具有多种用途。
相关类别
密度 1.02 g/mL at 20 °C
沸点 1700 °C
熔点 993 °C(lit.)
分子式 FNa
分子量 41.98820
闪点 1704°C
精确质量 41.98820
外观性状 白色无气味的粉末或晶体
蒸汽压 1.4 mm Hg ( 0 °C)
折射率 1.336
储存条件

储存注意事项储存于阴凉、干燥、通风良好的库房。库温不超过35℃,相对湿度不超过80%。包装密封。应与酸类、食用化学品分开存放,切忌混储。储区应备有合适的材料收容泄漏物。

稳定性

1.有毒,有腐蚀性。在100g水中的溶解度为4.0g(15℃),5.0g(100℃),不溶于乙醇。在水溶液中部分水解,故水溶液显碱性,饱和溶液的pH值为7.4。

2.稳定性 稳定

3.禁配物 强酸

4.聚合危害 不聚合

水溶解性 4 g/100 mL (25 ºC)
分子结构

1、摩尔折射率:无可用的

2、摩尔体积(cm3/mol):无可用的

3、等张比容(90.2K):无可用的

4、表面张力(dyne/cm):无可用的

5、介电常数:无可用的

6、极化率:无可用的

7、单一同位素质量:41.988173 Da

8、标称质量:42 Da

9、平均质量:41.9882 Da

计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:2

8.表面电荷:0

9.复杂度:2

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

更多

1.性状:白色粉末或结晶,无臭。

2.pH值:7.4(新配制的饱和溶液)

3.熔点(℃):986.9~996

4.沸点(℃):1695~1700

5.相对密度(水=1):2.56~2.79

6.饱和蒸气压(kPa):0.13(1077℃)

7.辛醇/水分配系数:-0.77

8.溶解性:溶于水,微溶于乙醇。

国标编号: 61513
CAS: 7681-49-4
中文名称: 氟化钠
英文名称: sodium fluoride
别 名:
分子式: NaF
分子量: 42.00
熔 点: 993℃
密 度: 相对密度(水=1)2.56
蒸汽压:
溶解性: 溶于水,微溶于醇
稳定性: 稳定
外观与性状: 白色粉末或结晶,无臭
危险标记: 15(有害品)
用 途: 用作杀虫剂、木材防腐剂

2.对环境的影响

该物质对环境可能有危害,对水体应给予特别注意。

一、健康危害

侵入途径:吸入、食入。 健康危害:急性中毒:多为误服所致。服后立即出现剧烈恶心、呕吐、腹痛、腹泻。重者休克、呼吸困难、紫绀。可能于2~4小时内死亡。部分患者出现荨麻疹,吞咽肌麻痹,手足抽搐或四肢肌肉痉挛。氟化钠粉尘和蒸气对皮肤有刺激作用,可以引起皮炎。 慢性影响:可引起氟骨症。

二、毒理学资料及环境行为

刺激性:家兔经皮:500mg(24小时),重度刺激。 亚急性和慢性毒性:大鼠以含氟化物7~9ppm的饲料连续喂养可引起牙钙化障碍,剂量增大则致骨骼改变。 致突变性:微生物致突变:鼠伤寒沙门氏菌1mg/皿。细胞遗传学分析:人成纤维细胞20mg/L。 生死毒性:大鼠经口最低中毒剂量(TDL0):240mg/kg(孕11~14天),肌肉骨骼发育异常。 致癌性:IARC致癌性评论:人不明确。

危险特性:未有特殊的燃烧爆炸特性。 燃烧(分解)产物:氟化氢。

3.现场应急监测方法

速测管法;离子选择电极法

4.实验室监测方法

离子选择性电极法(GB7484-87,水质,氟化物)氟试剂分光光度法(GB7483-87,水质,氟化物)滤膜氟离子选择电极法(GB/T15434-95,空气,氟化物)

5.环境标准

中 国 (TJ36-79) 车间空气中有害物质的最高容许浓度 1mg/m3[F]
中 国 (TJ36-79) 居住区大气中有害物质的最高容许浓度(氟化物) 0.02mg/m3(一次值);0.007mg/m3(日均值)
中国(GB16297-1996) 大气污染物综合排放标准(氟化物) ①最高允许排放浓度(mg/m3)
9~90(表2);11~100(表1)
②最高允许排放速率(kg/h)
二级0.10~4.2(表2);0.12~4.9(表1)
三级0.15~6.3(表2);0.18~7.5(表1)
③无组织排放监控浓度限值(mg/m3)
0.02(表2);0.02(表1)
中国(GB5048-92) 农田灌溉水质标准(氟化物) 2.0~3.0mg/L(水作,旱作,蔬菜)
中国(GB11607-89) 渔业水质标准 1mg/L(氟化物)
中国(GB5749-85) 生活饮用水卫生标准 1.0mg/L(氟化物)
中国(GB/T14848-93) 地下水质量标准(mg/L) I类1.0;II类1.0;III类1.0;IV类2.0;V类2.0以上(氟化物)
中国(GHZB1-1999)

地表水环境质量标准(mg/L)

I类1.0以下;II类1.0;III类1.0;IV类1.5; V类1.5(氟化物)

中国(GB8978-1996)

污水综合排放标准(mg/L)

一级10;二级10~20;三级20~30(氟化物)

中国(GB5058.3-1996) 固体废弃物浸出毒性鉴别标准值 50mg/L(氟化物)

6.应急处理处置方法

一、泄漏应急处理

隔离泄漏污染区,周围设警告标志,建议应急处理人员戴好防毒面具,穿相应的工作服。不要直接接触泄漏物。避免扬尘,用洁净的铲子收集于干燥、洁净、有盖的容器中。如大量泄漏收集回收或运至废物处理场所处置。

二、防护措施

呼吸系统防护:空气中浓度超标时,应该佩戴防毒口罩。紧急事态抢救或逃生时,建议佩戴自给式呼吸器。 眼睛防护:戴化学安全防护眼镜。 防护服:穿相应的防护服。 手防护:戴防化学品手套。 其它:工作现场禁止吸烟、进食和饮水。工作后,淋浴更衣。工作服不要带至非作业场所。单独存放被毒物污染的衣服,洗后备用。保持良好的卫生习惯。

三、急救措施

皮肤接触:脱去被污染的衣着,立即用流动清水彻底冲洗。 眼睛接触:立即提起眼睑,用流动清水冲洗10分钟或用2%碳酸氢钠溶液冲洗。 吸入:脱离现场至空气新鲜处。必要时进行人工呼吸。就医。 食入:患者清醒时给饮大量温水,催吐,尽快洗胃。就医。

灭火方法:不燃。火场周围可用的灭火介质。

毒理学数据:

1.急性毒性 LD50:52mg/kg(大鼠经口);57mg/kg(小鼠经口)

2.刺激性 家兔经眼:20mg(24h),中度刺激。

3.亚急性与慢性毒性 大鼠以含氟化物7~9ppm的饲料连续喂养可引起牙钙化障碍,剂量增大则致骨骼改变。

4.致突变性 微生物致突变:鼠伤寒沙门菌1mg/皿。细胞遗传学分析:人成纤维细胞20mg/L。程序外DNA合成:人成纤维细胞100mg/L。DNA抑制:人成纤维细胞100mg/L。

5.致畸性 大鼠孕后11~14d经口给予最低中毒剂量(TDLo)240mg/kg,致肌肉骨骼系统发育畸形。雌性大鼠交配前85d,经口给予最低中毒剂量(TDLo)255mg/kg,致中枢神经系统发育畸形。大鼠多代经口给予最低中毒剂量(TDLo)3.4mg/kg,致泌尿生殖系统发育畸形。

6.致癌性 IARC致癌性评论:G3,对人及动物致癌性证据不足。

7.其他 大鼠经口最低中毒剂量(TDLo):240mg/kg(孕11~14d),肌肉骨骼发育异常。

生态学数据:

1.生态毒性 暂无资料

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WB0350000
CHEMICAL NAME :
Sodium fluoride
CAS REGISTRY NUMBER :
7681-49-4
LAST UPDATED :
199806
DATA ITEMS CITED :
152
MOLECULAR FORMULA :
F-Na
MOLECULAR WEIGHT :
41.99
WISWESSER LINE NOTATION :
NA F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Behavioral - fluid intake Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1662 mg/kg
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - nausea or vomiting
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
214 ug/kg
TOXIC EFFECTS :
Behavioral - headache Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intradermal
SPECIES OBSERVED :
Human
DOSE/DURATION :
14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Immunological Including Allergic - increased immune response
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - tumors Sense Organs and Special Senses (Eye) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50830 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
155 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
26600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
448 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
420 mg/kg/6W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - somnolence (general depressed activity) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg/5D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
603 mg/kg/26W-I
TOXIC EFFECTS :
Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg/60D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Biochemical - Metabolism (Intermediary) - lipids including transport
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mg/kg/5H/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Musculoskeletal - changes in teeth and supporting structures Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 mg/kg/10D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg/14D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21840 mg/kg/26W-C
TOXIC EFFECTS :
Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
402 mg/kg/35D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5460 mg/kg/78W-I
TOXIC EFFECTS :
Gastrointestinal - malabsorption Blood - other changes Nutritional and Gross Metabolic - changes in calcium
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6930 mg/kg/99W-I
TOXIC EFFECTS :
Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium Nutritional and Gross Metabolic - changes in phosphorus
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3650 mg/kg/1Y-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1327 mg/kg/30D-I
TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12617 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors Musculoskeletal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2190 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4217 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4242 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4368 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
87 gm/kg/97W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
150 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
221 mg/kg
SEX/DURATION :
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
240 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
128 mg/kg
SEX/DURATION :
female 85 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
255 mg/kg
SEX/DURATION :
female 85 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
9 mg/kg
SEX/DURATION :
female 10-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
90 mg/kg
SEX/DURATION :
female 10-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
400 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1240 mg/kg
SEX/DURATION :
male 8 week(s) pre-mating female 8 week(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
620 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5600 ug/kg
SEX/DURATION :
lactating female 14 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin appendages
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 ng/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8800 mg/kg
SEX/DURATION :
male 2.4 year(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Mammal - species unspecified Lung
REFERENCE :
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 3,94,1983 *** REVIEWS *** ACGIH TLV-TWA 2.5 mg(F)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,237,1982 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,237,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,208,1987 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 400,5,1963 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 TOXICOLOGY REVIEW IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 19,535,1950 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2.5 mg(F)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,116,1971 OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993 OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993 OEL-DENMARK:TWA 2.5 mg(F)/m3 JAN 1993 OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993 OEL-FRANCE:TWA 2 mg/m3 JAN 1993 OEL-FRANCE:TWA 2.5 mg(F)/m3 JAN 1993 OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993 OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993 OEL-POLAND:TWA 1 mg(F)/m3 JAN 1993 OEL-RUSSIA:TWA 0.2 mg/m3;STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993 OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993 OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993 OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84425 No. of Facilities: 3763 (estimated) No. of Industries: 50 No. of Occupations: 50 No. of Employees: 25059 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84425 No. of Facilities: 3970 (estimated) No. of Industries: 83 No. of Occupations: 69 No. of Employees: 84776 (estimated) No. of Female Employees: 26602 (estimated)

符号 GHS06
GHS06
信号词 Danger
危害声明 H301-H315-H319
补充危害声明 Contact with acids liberates very toxic gas.
警示性声明 Missing Phrase - N15.00950417-P305 + P351 + P338
个人防护装备 Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲) T:Toxic
风险声明 (欧洲) R25;R32;R36/38
安全声明 (欧洲) S23-S24/25-S45-S36-S22
危险品运输编码 UN 1690 6.1/PG 3
WGK德国 1
RTECS号 WB0350000
包装等级 III
危险类别 6.1
海关编码 2826192010

1.熔浸法
将萤石、纯碱和石英砂,在高温(800~900℃)下煅烧,然后用水浸取,再经蒸发、结晶、干燥得成品。反应方程式如下:
7681-49-4 preparation

2.中和法
用纯碱或烧碱中和氢氟酸而得,反应方程式如下:
7681-49-4 preparation
在中和锅内用母液溶解纯碱,然后加入30%的氢氟酸中和至pH值8~9,且有CO2气体逸出为止,氢氟酸中往往含有氟硅酸杂质,中和后生成氟硅酸钠;在90~95℃:下加热1h,氟硅酸钠即分解:反应方程式如下:
7681-49-4 preparation
中和过程中pH值不得低于8,不然氟硅酸钠难被碱分解,中和液静置1h,清液经浓缩后冷却析出氟化钠结晶,再经离心分离、干燥、粉碎得成品。

3.氟硅酸钠法
由湿法磷酸和磷肥副产的氟硅酸,按常规方法可制得99.87%的氟硅酸钠。在84~95℃和0.15MPa的条件下反应160~180min、过量5%~8%的碱性溶液(pH值为8~9)中,生成氟化钠。反应方程式如下:
7681-49-4 preparation
中和液静置澄清后,清液经蒸发浓缩、冷却结晶,分离后用50~60℃的热水洗涤,间接干燥得成品。

4.工业上制备氟化钠由氟硅酸钠作原料。在聚乙烯的烧杯中将45g氟硅酸钠溶于50g水中,加热至80℃,在搅拌下缓缓加入50.7g碳酸钠,接着加入49% NaOH水溶液39g,加热至95℃以上,即有氟化钠沉淀生成,抽滤,用水充分洗涤数遍,干燥。可得58g氟化钠。纯度可达99%。

5.制取高纯度的氟化钠,可使氢氟酸与碳酸钠、碳酸氢钠或氢氧化钠作用。在聚乙烯的烧杯中,加入50g 46%的氢氟酸,加水42g稀释,使浓度为25%。加计算量的NaOH水溶液,氟化钠沉淀立即生成,吸滤,用水充分洗涤。在烘箱中于110℃烘干。为制取极纯品,可用高纯度的氢氟酸与碳酸氢钠中和,至弱酸性即达终点,沉淀在550~650℃下干燥即可。

海关编码 2826192010