毒理学数据:
1、皮肤/眼睛刺激性
标准的Draize试验:兔子,皮肤接触:500mg/24H,反应的严重程度:中度。
标准的Draize试验:兔子,眼睛接触:50μg/24H,反应的严重程度:严重。
2、急性毒性:大鼠经口LD50:485mg/kg;小鼠经口LD50:350mg/kg;小鼠经吸入LC50:10mg/m3/2H;小鼠经腹腔LD50:10mg/kg;小鼠经静脉LD50:18mg/kg;
3、其他多剂量毒性:大鼠经口TDLo:2800mg/kg/28D-C;
大鼠经吸入TCLo:1880μg/m3/4H/11W-I;
4、 慢性毒性/致癌性
大鼠经口TDLo:20mg/kg/73W-I;大鼠经多重线路TDLo:16mg/kg/73W-I
生态学数据:
该物质对环境有危害,应特别注意对水体的污染。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XZ1400000
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CHEMICAL NAME :
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s-Triazine, 2,4,6-trichloro-
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CAS REGISTRY NUMBER :
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108-77-0
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BEILSTEIN REFERENCE NO. :
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0124246
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C3-Cl3-N3
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MOLECULAR WEIGHT :
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184.41
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WISWESSER LINE NOTATION :
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T6N CN ENJ BG DG FG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,152,1972 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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485 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
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REFERENCE :
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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350 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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10 mg/m3/2H
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TOXIC EFFECTS :
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Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
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REFERENCE :
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4891,1982
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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18 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07336 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2800 mg/kg/28D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Related to Chronic Data - death
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REFERENCE :
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TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,119,1992
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1880 ug/m3/4H/11W-I
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TOXIC EFFECTS :
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Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
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REFERENCE :
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(8),35,1968 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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20 gm/kg/73W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors
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REFERENCE :
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VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Multiple routes
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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16 gm/kg/73W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
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REFERENCE :
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VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 12(4),78,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4559 No. of Facilities: 20 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2336 (estimated) No. of Female Employees: 299 (estimated)
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