5657-61-4

• 常用中文名：尼可马特
• 常用英文名：E 537
• CAS号：5657-61-4
• 分子式：C₆H₆N₂O₂
• 分子量：138.12400
• 发布时间：2018-03-25 08:00:00
• 更新时间：2025-08-29 10:40:43

名称

• 中文名: 尼可马特
• 英文名: N-hydroxypyridine-3-carboxamide
• 英文别名: Nicoxamat; 3-picolinehydroxamic acid; E 537; 3-pyridinehydroxamic acid; nicotinic acid hydroxamate; N-Hydroxy-3-pyridinecarboxamide; Nicotinohydroximic acid; Nicotinohydroxamsaeure; N-Hydroxynicotinamid; Nicotine hydroxamic acid; nicotinohydroxamic acid; 3-Pyridinecarboxamide,N-hydroxy; 3-pyridinecarbohydroxamic acid; Nicotinylhydroxamic acid

物化性质

• 密度: 1.328g/cm3
• 分子式: C₆H₆N₂O₂
• 分子量: 138.12400
• 精确质量: 138.04300
• PSA: 62.22000
• LogP: 0.59150
• 折射率: 1.585
• 储存条件: 2-8°C， 密封， 干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US4666100 CHEMICAL NAME : 3-Pyridinecarboxamide, N-hydroxy- CAS REGISTRY NUMBER : 5657-61-4 BEILSTEIN REFERENCE NO. : 0003657 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H6-N2-O2 MOLECULAR WEIGHT : 138.14 WISWESSER LINE NOTATION : T6NJ CVMQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36

合成路线

614-18-6 ~% 5657-61-4

文献：Shavel et al. Journal of the American Pharmaceutical Association (1912-1977), 1953 , vol. 42, p. 402,405 Full Text Show Details Anderson et al. Journal of Biological Chemistry, 1959 , vol. 234, p. 1219

93-60-7 ~66% 5657-61-4

文献：Mulcahy, Clodagh; Dolgushin, Fedor M.; Krot, Krystyna A.; Griffith, Darren; Marmion, Celine J. Dalton Transactions, 2005 , # 11 p. 1993 - 1998 Title/Abstract Full Text View citing articles Show Details Mulcahy, Clodagh; Krot, Krystyna A.; Griffith, Darren M.; Suponitsky, Kyrill Yu.; Starikova, Zoya A.; Marmion, Celine J. European Journal of Inorganic Chemistry, 2007 , # 10 p. 1373 - 1380

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