126-99-8

126-99-8结构式
126-99-8结构式

化源商城直购

中文名 2-氯-1,3-丁二烯
英文名 chloroprene
中文别名 2-氯丁二烯
氯代丁二烯
英文别名 Chloropren
Chloropreen
1,3-BUTADIENE,2-CHLORO-
Baypren EM1
2-chloro-buta-1,3-diene
2-CHLOROBUTA-1,3-DIENE
Baypren M1
Neoprene AH
2 chloro 1,3 butadiene
MFCD00014928
Chloroprene
Baypren 310
Baypren 110
2-chloro-butadiene
2-CHLORO-1,3-BUTADIENE
CHLOROPENE
2-chloro-1,2-butadiene
Cloroprene
Baypren 216
EINECS 204-818-0
密度 0,958 g/cm3
沸点 59.4ºC at 760mmHg
分子式 C4H5Cl
分子量 88.53550
闪点 11 °C
精确质量 88.00800
LogP 1.92490
外观性状 透明无色液体
折射率 1.445
储存条件

储存注意事项 通常商品加有阻聚剂。储存于阴凉、通风的库房。远离火种、热源。库温不宜超过29℃。包装要求密封,不可与空气接触。应与氧化剂、酸类、食用化学品分开存放,切忌混储。不宜大量储存或久存。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。

稳定性

1.刺激性极强,主要表现在对中枢神经系统及呼吸道等的损害。在浓度为100*10-6下中毒时能引起头痛、全身无力、嗜睡、记忆力减弱,也能引起肝、肾损害、血压下降、脱毛、秃发,并损害生殖细胞。因此,有2-氯-1,3-丁二烯蒸气存在的工序不允许女工参加。2-氯-1,3-丁二烯蒸气除能被吸入外,也能经皮肤吸收。空气中最高容许浓度90mg/m3。应特别强调远距离仪表控制操作,严防跑、冒、滴、漏。加强防护措施,强制排风。操作人员应穿戴防护用具。

2.稳定性 稳定

3.禁配物 强氧化剂、酸类

4.避免接触的条件 受热,接触空气

5.聚合危害 聚合

6.分解产物 氯化氢

分子结构

1、摩尔折射率:24.72

2、摩尔体积(cm3/mol):95.9

3、等张比容(90.2K):203.9

4、表面张力(dyne/cm):20.4

5、极化率(10-24cm3):9.80

计算化学

1、疏水参数计算参考值(XlogP):2.3

2、氢键供体数量:0

3、氢键受体数量:0

4、可旋转化学键数量:1

5、互变异构体数量:无

6、拓扑分子极性表面积(TPSA):0

7、重原子数量:5

8、表面电荷:0

9、复杂度:54.7

10、同位素原子数量:0

11、确定原子立构中心数量:0

12、不确定原子立构中心数量:0

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:1

更多

1.性状:无色液体,有醚的气味。

2.熔点(℃):-130

3.沸点(℃):59.4

4.相对密度(水=1):0.96

5.相对蒸气密度(空气=1):3.0

6.饱和蒸气压(kPa):23.2(20℃)

7.临界压力(MPa):4.26

8.辛醇/水分配系数:2.53

9.闪点(℃):-20(OC)

10.引燃温度(℃):320

11.爆炸上限(%):20.0

12.爆炸下限(%):4.0

13.溶解性:微溶于水,溶于乙醇、乙醚、丙酮、苯等多数有机溶剂。

第一部分:化学品名称
化学品中文名称:
2- -1,3- 丁二烯 ( 抑制了的 )
化学品英文名称:
2-chloro-1,3-butadiene
中文名称 2
氯代丁二烯
英文名称 2
技术说明书编码:
200
CAS No.
126-99-8
分子式:
C4H5Cl
分子量:
88.54
第二部分:成分 / 组成信息
有害物成分
含量
CAS No.
2- -1,3- 丁二烯 ( 抑制了的 )
126-99-8
第三部分:危险性概述
危险性类别:
侵入途径:
健康危害:
以中枢神经系统抑制和呼吸道刺激作用为主。急性中毒:短期吸入高浓度蒸气出现流泪、咽干痛、胸闷、呼吸困难;结膜及咽部充血;肺部散在罗音;并有头昏、头痛、乏力、四肢麻木、步态不稳、恶心、呕吐、昏迷、抽搐等。个别发生急性肺水肿而死亡。急性期后可出现肝、肾损害及脱发。慢性中毒:长期密切接触可引起神经衰弱综合征、中毒性肝病。重者出现肝硬变。多数患者有脱发,可伴有眉毛、腋毛、睫毛脱落,指甲变灰褐色。血清β - 球蛋白自身比较降低 20 %以上。
环境危害:
燃爆危险:
本品极度易燃,具刺激性。
第四部分:急救措施
皮肤接触:
脱去污染的衣着,用肥皂水和清水彻底冲洗皮肤。
眼睛接触:
提起眼睑,用流动清水或生理盐水冲洗。就医。
吸入:
迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难,给输氧。如呼吸停止,立即进行人工呼吸。就医。
食入:
饮足量温水,催吐。就医。
第五部分:消防措施
危险特性:
其蒸气与空气可形成爆炸性混合物,遇明火、高热能引起燃烧爆炸。受高热分解产生有毒的氯化物气体。与强氧化剂发生反应 , 可引起燃烧。若遇高热,可发生聚合反应,放出大量热量而引起容器破裂和爆炸事故。其蒸气比空气重,能在较低处扩散到相当远的地方,遇火源会着火回燃。
有害燃烧产物:
一氧化碳、二氧化碳、氯化氢。
灭火方法:
尽可能将容器从火场移至空旷处。喷水保持火场容器冷却,直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音,必须马上撤离。灭火剂:泡沫、二氧化碳、干粉、砂土。用水灭火无效。
第六部分:泄漏应急处理
应急处理:
迅速撤离泄漏污染区人员至安全区,并进行隔离,严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器,穿防静电工作服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏:用大量水冲洗,洗水稀释后放入废水系统。大量泄漏:构筑围堤或挖坑收容。用泡沫覆盖,降低蒸气灾害。用防爆泵转移至槽车或专用收集器内,回收或运至废物处理场所处置。
第七部分:操作处置与储存
操作注意事项:
密闭操作,加强通风。操作人员必须经过专门培训,严格遵守操作规程。建议操作人员佩戴过滤式防毒面具(半面罩),戴化学安全防护眼镜,穿防静电工作服,戴橡胶耐油手套。远离火种、热源,工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类接触。搬运时要轻装轻卸,防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项:
通常商品加有阻聚剂。储存于阴凉、通风的库房。远离火种、热源。库温不宜超过 30 ℃。包装要求密封,不可与空气接触。应与氧化剂、酸类、食用化学品分开存放,切忌混储。不宜大量储存或久存。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
第八部分:接触控制 / 个体防护
职业接触限值
中国 MAC(mg/m3)
4[ ]
前苏联 MAC(mg/m3)
3
TLVTN
ACGIH 10ppm,36mg/m3[ ]
TLVWN
未制定标准
监测方法:
气相色谱法
工程控制:
生产过程密闭,加强通风。提供安全淋浴和洗眼设备。
呼吸系统防护:
空气中浓度超标时,佩戴过滤式防毒面具(半面罩)。
眼睛防护:
戴化学安全防护眼镜。
身体防护:
穿防静电工作服。
手防护:
戴橡胶耐油手套。
其他防护:
工作现场禁止吸烟、进食和饮水。工作完毕,淋浴更衣。注意个人清洁卫生。
第九部分:理化特性
主要成分:
纯品
外观与性状:
无色液体,有辛辣气味。
pH
熔点 ( )
无资料
沸点 ( )
59.4
相对密度 ( =1)
0.96
相对蒸气密度 ( 空气 =1)
3.0
饱和蒸气压 (kPa)
无资料
燃烧热 (kJ/mol)
无资料
临界温度 ( )
无资料
临界压力 (MPa)
无资料
辛醇 / 水分配系数的对数值:
无资料
闪点 ( )
-20
引燃温度 ( )
无资料
爆炸上限 %(V/V)
4.0
爆炸下限 %(V/V)
20.0
溶解性:
微溶于水,溶于乙醇、乙醚等多数有机溶剂。
主要用途:
重要有机化工原料,用作有机合成中间体、氯丁橡胶的单体等。
其它理化性质:
第十部分:稳定性和反应活性
稳定性:
禁配物:
强氧化剂、酸类。
避免接触的条件:
受热、光照。
聚合危害:
分解产物:
第十一部分:毒理学资料
急性毒性:
LD50 900 mg/kg( 大鼠经口 ) 260 mg/kg( 小鼠经口 )

LC50
:无资料
亚急性和慢性毒性:
刺激性:
致敏性:
致突变性:
致畸性:
致癌性:
第十二部分:生态学资料
生态毒理毒性:
生物降解性:
非生物降解性:
生物富集或生物积累性:
其它有害作用:
无资料。
第十三部分:废弃处置
废弃物性质:
废弃处置方法:
处置前应参阅国家和地方有关法规。建议用焚烧法处置。与燃料混合后,再焚烧。焚烧炉排出的卤化氢通过酸洗涤器除去。
废弃注意事项:
第十四部分:运输信息
危险货物编号:
31013
UN 编号:
1991
包装标志:
包装类别:
O51
包装方法:
小开口钢桶;安瓿瓶外普通木箱;螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶(罐)外普通木箱。
运输注意事项:
运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备。夏季最好早晚运输。运输时所用的槽(罐)车应有接地链,槽内可设孔隔板以减少震荡产生静电。严禁与氧化剂、酸类、食用化学品等混装混运。运输途中应防曝晒、雨淋,防高温。中途停留时应远离火种、热源、高温区。装运该物品的车辆排气管必须配备阻火装置,禁止使用易产生火花的机械设备和工具装卸。公路运输时要按规定路线行驶,勿在居民区和人口稠密区停留。铁路运输时要禁止溜放。严禁用木船、水泥船散装运输。
第十五部分:法规信息
法规信息
化学危险物品安全管理条例 (1987 2 17 日国务院发布 ) ,化学危险物品安全管理条例实施细则 ( 化劳发 [1992] 677 ) ,工作场所安全使用化学品规定 ([1996] 劳部发 423 ) 等法规,针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定;常用危险化学品的分类及标志 (GB 13690-92) 将该物质划为第 3.1 类低闪点易燃液体;车间空气中氯丁二烯卫生标准 (GB 16202-1996) ,规定了车间空气中该物质的最高容许浓度及检测方法。
第十六部分:其他信息
参考文献:
填表时间:
填表部门:
数据审核单位:
修改说明:
其他信息:
MSDS 修改日期:

毒理学数据:

1.急性毒性

LD50:450mg/kg(大鼠经口);260mg/kg(小鼠经口)

LC50:11800mg/m3(大鼠吸入,4h)

2.刺激性 家兔经皮:500μl(24h),重度刺激。

3.亚急性与慢性毒性大、小鼠吸入100~350mg/m3,每天8h,共6个月,发生阑尾溃疡,肝、心肌改变,淋巴组织和脾、髓网状细胞增殖等。

4.致突变性 微生物致突变:鼠伤寒沙门菌70μmol/L。细胞遗传学分析:大鼠吸入1960μg/m3(16周)。显性致死试验:大鼠吸入4μg/L(48d)(间断性)。

5.致畸性 鼠孕后11~12d经口给予最低中毒剂量(TDLo)1mg/kg,致中枢神经系统发育畸形。

6.致癌性 IARC致癌性评论:G2B,可疑人类致癌物。

7.其他 大鼠经口最低中毒剂量(TDLo):1mg/kg(孕3~4d),引起胚胎毒性。大鼠吸入最低中毒浓度(TCLo):4mg/m3(24h)(孕3~4d),引起死胎。

生态学数据:

1.生态毒性 暂无资料

2.生物降解性

好氧生物降解(h):672~4320

厌氧生物降解(h):2688~17280

3.非生物降解性 空气中光氧化半衰期(h):2.9~27.8

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EI9625000
CHEMICAL NAME :
1,3-Butadiene, 2-chloro-
CAS REGISTRY NUMBER :
126-99-8
LAST UPDATED :
199712
DATA ITEMS CITED :
78
MOLECULAR FORMULA :
C4-H5-Cl
MOLECULAR WEIGHT :
88.54
WISWESSER LINE NOTATION :
1UYG1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11800 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
146 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1290 mg/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3870 mg/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
96 mg/kg
TOXIC EFFECTS :
Blood - other changes Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
13 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 ug/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1680 mg/kg/3W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
161 ppm/6H/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 ug/m3/24H/60D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/m3/24H/91D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Gastrointestinal - ulceration or bleeding from large intestine Blood - changes in spleen
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
63 mg/m3/21D-I
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1260 mg/m3/14D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/m3/24H/91D-C
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from large intestine Blood - changes in spleen Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg/21D-I
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
162 ppm/6H/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9100 ug/kg
SEX/DURATION :
male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 mg/kg
SEX/DURATION :
female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 mg/kg
SEX/DURATION :
female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 mg/kg
SEX/DURATION :
female 9-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4 mg/m3/24H
SEX/DURATION :
female 3-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4 mg/m3/24H
SEX/DURATION :
female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 ppm/4H
SEX/DURATION :
female 3-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
150 ug/m3/24H
SEX/DURATION :
male 19 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
500 mg/m3/5H
SEX/DURATION :
female 17 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
500 mg/m3/5H
SEX/DURATION :
female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Embryo
REFERENCE :
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** ACGIH TLV-TWA 36 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,131,1979 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,131,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,160,1987 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 13,153,1978 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (90 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,54,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (35 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (36 mg/m3);Skin JAN 1993 OEL-DENMARK:STEL 1 ppm (3.6 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 10 ppm (36 mg/m3);STEL 20 ppm (72 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (36 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (36 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 10 mg/m3;STEL 30 mg/m3 JAN 1993 OEL-POLAND:TWA 2 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3 JAN 1993 OEL-SWEDEN:TWA 10 ppm (35 mg/m3);STEL 15 ppm (60 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (36 mg/m3);STEL 20 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO beta-CHLOROPRENE-air:CA CL 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18260 No. of Facilities: 3538 (estimated) No. of Industries: 39 No. of Occupations: 26 No. of Employees: 43712 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18260 No. of Facilities: 1864 (estimated) No. of Industries: 17 No. of Occupations: 21 No. of Employees: 17750 (estimated) No. of Female Employees: 654 (estimated)

符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger
危害声明 H225-H301 + H311 + H331-H350-H370
警示性声明 P201-P210-P260-P280-P301 + P310-P311
个人防护装备 Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲) F,T
风险声明 (欧洲) R10
安全声明 (欧洲) S16-S45-S53-S36/37-S7
危险品运输编码 1993
包装等级 I
危险类别 3.1

1.由乙炔二聚得到的乙烯基乙炔与氯化氢加成而得。生产1t氯丁二烯消耗乙烯基乙炔约750kg、氯化氢约500kg。

126-99-8 preparation

2.由丁二烯氯化得二氯丁烯,再脱氯化氢而得:由丁二烯氯化所得的二氯丁烯为3,4-二氯丁烯-1和1,4-二氯丁烯-2的混合物。由于制氯丁二烯需要3,4-二氯丁烯-2,故需将1,4-异构物转化为3,4-异构物。其方法是将混合物在氯化亚铜存在下,于130-145℃进行蒸馏,即可将1,4-异构物转化为沸点较低的3,4-异构物(从塔顶出来即可用于脱氯化氢制氯丁二烯)。1,4-二氯丁烯-2在85℃下用稀碱液脱氯化氢即生成2-氯丁二烯。

126-99-8 preparation