3772-76-7

• 常用中文名：磺胺托嘧啶
• 常用英文名：Sulfamethomidine
• CAS号：3772-76-7
• 分子式：C₁₂H₁₄N₄O₃S
• 分子量：294.33000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-06-12 14:16:17
• 更新时间：2024-01-02 23:54:21
• 磺胺甲脒是一种抗菌剂[1]。

名称

• 中文名: 磺胺托嘧啶
• 英文名: 4-amino-N-(6-methoxy-2-methylpyrimidin-4-yl)benzenesulfonamide
• 英文别名: Methofazine; N1-<6-Methoxy-2-methyl-pyrimidinyl-(4)>-sulfanilamid; 4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)-benzenesulfonamide; Duroprocin; Sulfametomidina [INN-Spanish]; Sulfamethomidine; Sulfametomidine; Methofadin; Sulfanilsaeure-(6-methoxy-2-methyl-pyrimidin-4-ylamid); sulfanilic acid-(6-methoxy-2-methyl-pyrimidin-4-ylamide); SA 412; EINECS 223-219-5; Sulfametomidinum [INN-Latin]; Solfametomidina [DCIT]; 4-<4-Amino-benzolsulfonylamino>-6-methoxy-2-methyl-pyrimidin; Sulfamethomidin

物化性质

• 密度: 1.418g/cm3
• 沸点: 501.6ºC at 760mmHg
• 分子式: C₁₂H₁₄N₄O₃S
• 分子量: 294.33000
• 闪点: 257.2ºC
• 精确质量: 294.07900
• PSA: 115.58000
• LogP: 2.91160
• 折射率: 1.633

生物活性

• 描述: 磺胺甲脒是一种抗菌剂[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. TRUANT JP, et al. ENHANCEMENT OF INHIBITORY EFFECT AGAINST GRAM-NEGATIVE ORGANISMS WITH COLISTIN SULFATE AND CERTAIN SULFONAMIDES. Antimicrob Agents Chemother (Bethesda). 1963;161:420-426.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WP0110000 CHEMICAL NAME : Sulfanilamide, N(sup 1)-(6-methoxy-2-methyl-4-pyrimidinyl)- CAS REGISTRY NUMBER : 3772-76-7 BEILSTEIN REFERENCE NO. : 0284949 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C12-H14-N4-O3-S MOLECULAR WEIGHT : 294.36 WISWESSER LINE NOTATION : T6N CNJ B1 DO1 FMSWR DZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3 gm/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 6 gm/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3 gm/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973

安全

• 海关编码: 2935009090

合成路线

23132-67-4 ~% 3772-76-7

文献：Loop; Luehrs Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 225,233 Full Text Show Details Nordmark-Werke Patent: DE926131 , 1951 ;

121-60-8 ~% 3772-76-7

文献：Loop; Luehrs Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 225,233 Full Text Show Details Nordmark-Werke Patent: DE926131 , 1951 ;

13394-85-9 ~% 3772-76-7

文献：Loop; Luehrs Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 225,233 Full Text Show Details Nordmark-Werke Patent: DE926131 , 1951 ;

103641-55-0 ~% 3772-76-7

文献：Loop; Luehrs Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 225,233 Full Text Show Details Nordmark-Werke Patent: DE926131 , 1951 ;

1780-26-3 121-61-9 ~% 3772-76-7

文献：Nordmark-Werke Patent: DE926131 , 1951 ;

上下游产品

上游产品  5
23132-67-4 121-60-8 13394-85-9 1780-26-3
121-61-9
下游产品  0

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%