相关CAS号：
96-29-7 696-29-7
2475-93-6 2224-33-1
7431-25-6 68172-63-4
90713-76-1 83817-72-5
34681-23-7 68083-48-7

96-29-7

96-29-7结构式
96-29-7结构式
  • 常用中文名：2-丁酮肟
  • 常用英文名：2-BUTANONE OXIME
  • CAS号：96-29-7
  • 分子式：C4H9NO
  • 分子量：87.120
  • 相关类别： 有机原料 烃类化合物及其衍生物 环烃
  • 发布时间：2018-07-18 16:54:08
  • 更新时间：2024-01-02 12:51:08
  • 【用途一】
    用于有机合成
    【用途二】
    用于各种油基漆、醇酸漆、环氧酯漆等储运过程中的防结皮处理，也可用作硅固化剂
    【用途三】
    主要用于醇酸树脂涂料防结皮剂和硅固化剂。该品作为防止结皮的抗氧剂使用，比丁醛肟、环己酮肟的效果好。
    【用途四】
    涂料油漆油墨防结皮剂、异氰酸酯封闭剂、有机硅交联剂、有机合成中间体。

化源商城直购

中文名 2-丁酮肟
英文名 Ethyl Methyl Ketoxime
中文别名 乙基甲基酮肟
丁酮肟
甲乙酮肟
甲基乙基酮肟
英文别名 (2E)-N-Hydroxybutan-2-imine
2-BUTANONE OXIME
2-Butanone, oxime, (2E)-
MFCD00013935
EINECS 202-496-6
(2E)-N-Hydroxy-2-butanimine
密度 0.9±0.1 g/cm3
沸点 152.5±0.0 °C at 760 mmHg
熔点 -30 °C
分子式 C4H9NO
分子量 87.120
闪点 60.0±0.0 °C
精确质量 87.068413
PSA 32.59000
LogP 0.65
外观性状 透明液体
蒸汽密度 3 (vs air)
蒸汽压 1.9±0.5 mmHg at 25°C
折射率 1.422
储存条件

1.储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂分开存放，切忌混储。

2.配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性

避免与酸、氧化物接触。

水溶解性 114 g/L (20 ºC)
分子结构

1、 摩尔折射率：24.51

2、 摩尔体积（cm3/mol）：96.5

3、 等张比容（90.2K）：219.1

4、 表面张力（dyne/cm）：26.5

5、 极化率（10-24cm3）：9.71
计算化学

1、 疏水参数计算参考值（XlogP）：0.7

2、 氢键供体数量：1

3、 氢键受体数量：2

4、 可旋转化学键数量：1

5、 互变异构体数量：2

6、 拓扑分子极性表面积（TPSA）：32.6

7、 重原子数量：6

8、 表面电荷：0

9、 复杂度：58.6

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：1

14、不确定化学键立构中心数量：0

15、共价键单元数量：1
更多

1. 性状：无色油状液体。

2. 密度（g/mL,25/4℃）：0.9232

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：-29.5

5. 沸点（ºC,常压）：152～153

6. 沸点（ºC,5.2kPa）：未确定

7. 折射率： 1.4410

8. 闪点（ºC）：60

9. 比旋光度（º）：未确定

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（kPa,25ºC）：未确定

12. 饱和蒸气压（kPa,60ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：50

18. 爆炸下限（%,V/V）：3.1

19. 溶解性：能与乙醇、乙醚混溶，溶于10份水中。
Name: 2-Butanone oxime 99% Material Safety Data Sheet
Synonym: Ethyl methyl ketone oxime; Ethyl methyl ketoxime; 2-Butanone oxime; Methyl ethyl ketoxime; MEK-oxime
CAS: 96-29-7
Section 1 - Chemical Product MSDS Name:2-Butanone oxime 99% Material Safety Data Sheet
Synonym:Ethyl methyl ketone oxime; Ethyl methyl ketoxime; 2-Butanone oxime; Methyl ethyl ketoxime; MEK-oxime
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
96-29-7 Methyl ethyl ketoxime 99 202-496-6
Hazard Symbols: XN
Risk Phrases: 21 40 41 43
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful in contact with skin. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes. May cause sensitization by skin contact.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed.
Overexposure may cause methemoglobinemia.
Inhalation:
Not available.
Chronic:
Chronic exposure may cause liver damage.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 96-29-7: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: clear colorless to pale yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: 0.904 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 152.5 deg C @ 760 mm Hg
Freezing/Melting Point: -29.5 deg C
Autoignition Temperature: Not available.
Flash Point: 59 deg C ( 138.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Slightly soluble.
Specific Gravity/Density: .9200 g/cm3
Molecular Formula: C4H9NO
Molecular Weight: 87.12
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 96-29-7: EL9275000 LD50/LC50:
CAS# 96-29-7: Draize test, rabbit, eye: 100 uL Severe; Oral, mouse: LD50 = 1 gm/kg; Oral, rat: LD50 = 930 mg/kg; Skin, rabbit: LD50 = 200 uL/kg.
Skin, rabbit: LD50 = 200 uL/kg = 184 mg/kg.
Carcinogenicity:
Methyl ethyl ketoxime - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: FLAMMABLE LIQUIDS, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing Group: III
IMO
Shipping Name: FLAMMABLE LIQUIDS, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing Group: III
RID/ADR
Shipping Name: FLAMMABLE LIQUIDS, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing group: III
Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 21 Harmful in contact with skin.
R 40 Limited evidence of a carcinogenic effect.
R 41 Risk of serious damage to eyes.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 13 Keep away from food, drink and animal feeding
stuffs.
S 23 Do not inhale gas/fumes/vapour/spray.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 96-29-7: 1
Canada
CAS# 96-29-7 is listed on Canada's DSL List.
CAS# 96-29-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 96-29-7 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、皮肤/眼睛刺激性

标准的Draize试验：兔子，眼睛接触：100μL，反应的严重程度：严重。

1、 急性毒性：大鼠经口LD50：930mg/kg；大鼠经吸入LD50：＞50mg/m3/4H；大鼠经皮肤接触LD：＞2mg/kg；大鼠经皮下LD50：2702mg/kg；小鼠经腹腔LD50：200mg/kg；兔子经皮肤接触LD50：200μg/kg；

2、 其他多剂量毒性：大鼠经口TDLo：6825mg/kg/13W-I；大鼠经吸入TCLo：400ppm/6H/4W-I；大鼠经吸入TCLo：1000ppm/6H/8W-I；大鼠经皮下TDLo：14mL/kg/4W-I；小鼠经吸入TCLo：400ppm/6H/4W-I；小鼠经吸入TCLo：1000ppm/6H/8W-I；

4、 慢性毒性/致癌性

大鼠经吸入TCLo：75ppm/6H/26W-I；

5、 致突变性

小鼠淋巴细胞突变：4600mg/L；

生态学数据:

该物质对水有稍微的危害。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL9275000
CHEMICAL NAME :
2-Butanone, oxime
CAS REGISTRY NUMBER :
96-29-7
BEILSTEIN REFERENCE NO. :
1698241
LAST UPDATED :
199712
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C4-H9-N-O
MOLECULAR WEIGHT :
87.14
WISWESSER LINE NOTATION :
QNUY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
930 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>50 gm/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2702 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6825 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 ppm/6H/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/6H/8W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 mL/kg/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Endocrine - changes in spleen weight Blood - changes in spleen
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 ppm/6H/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 ppm/6H/8W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 ppm/6H/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
4600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,149,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1326 No. of Facilities: 60 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 180 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82905 No. of Facilities: 1540 (estimated) No. of Industries: 15 No. of Occupations: 36 No. of Employees: 12114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82905 No. of Facilities: 26030 (estimated) No. of Industries: 192 No. of Occupations: 112 No. of Employees: 313185 (estimated) No. of Female Employees: 25609 (estimated)

符号 GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
信号词 Danger
危害声明 H312-H317-H318-H351
警示性声明 P280-P305 + P351 + P338
个人防护装备 Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲) Xn:Harmful;
风险声明 (欧洲) R21;R40;R41;R43
安全声明 (欧洲) S13-S23-S26-S36/37/39-S61-S45-S36/37-S25
危险品运输编码 UN 1993 3/PG 3
WGK德国 1
RTECS号 EL9275000
包装等级 III
危险类别 3
海关编码 29280090
1.由丁酮和盐酸羟胺反应而得。也可以由丁酮与硫酸羟胺反应。 2.以甲乙酮、氢氮化铵、硫酸为原料，反应制得。反应式如下： 96-29-7 preparation
海关编码 2928000090
中文概述 2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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