405165-61-9

• 常用中文名：盐酸贝西沙星
• 常用英文名：Besifloxacin HCl
• CAS号：405165-61-9
• 分子式：C₁₉H₂₂Cl₂FN₃O₃
• 分子量：430.301
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-06-22 14:09:05
• 更新时间：2024-01-02 09:47:39
• Besifloxacin盐酸盐是第四代氟喹诺酮类抗生素。

名称

• 中文名: 盐酸贝西沙星
• 英文名: Besifloxacin Hydrochloride
• 中文别名: 贝西沙星盐酸盐; 贝西沙星
• 英文别名: Besifloxacin HCl; 3-Quinolinecarboxylic acid, 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1); 7-[(3R)-3-Amino-1-azepanyl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1); Besifloxacin hydrochloride

物化性质

• 沸点: 607ºC at 760 mmHg
• 熔点: >210ºC (dec.)
• 分子式: C₁₉H₂₂Cl₂FN₃O₃
• 分子量: 430.301
• 闪点: 320.9ºC
• 精确质量: 429.102234
• PSA: 88.56000
• LogP: 4.71200
• 外观性状: 淡黄色固体
• 储存条件: Refrigerator

生物活性

• 描述: Besifloxacin盐酸盐是第四代氟喹诺酮类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Wang Z, Wang S, Zhu F, Chen Z, Yu L, Zeng S. Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization. Chirality. 2012 Jul;24(7):526-31. doi: 10.1002/chir.22042.

  [2]. Hussar DA. New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine. J Am Pharm Assoc (2003). 2009 Jul-Aug;49(4):570-4.

  [3]. Nafziger AN, Bertino JS Jr. Besifloxacin ophthalmic suspension for bacterial conjunctivitis. Drugs Today (Barc). 2009 Aug;45(8):577-88.

  [4]. Proksch JW, Ward KW. Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits. J Ocul Pharmacol Ther. 2010 Oct;26(5):449-58.

  [5]. Comstock TL, Paterno MR, Usner DW, Pichichero ME. Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group,