13647-35-3

• 常用中文名：曲洛司坦
• 常用英文名：Trilostane
• CAS号：13647-35-3
• 分子式：C₂₀H₂₇NO₃
• 分子量：329.433
• 相关类别： 无机化工 无机盐 金属硝酸盐及亚硝酸盐
• 发布时间：2018-05-27 08:00:00
• 更新时间：2024-01-01 18:43:04
• Trilostane(Win 24540; Modrastane)是3 β-羟化类固醇脱氢酶抑制剂，可作用于库兴氏综合征。

名称

• 中文名: 曲洛斯坦
• 英文名: trilostane
• 中文别名: 曲洛司坦; 曲龙斯坦
• 英文别名: MODRASTANE; (4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile; 2a-Cyano-4a,5a-epoxyandrostan-17b-ol-3-one; Desopan; Trilostane; MFCD00199295; Modrenal; (4α,5α,17β)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile; Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-; Modrefen; Vetoryl; EINECS 237-133-0; 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile; Trilostane(Win 24540; Modrastane)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 497.8±45.0 °C at 760 mmHg
• 熔点: 264ºC
• 分子式: C₂₀H₂₇NO₃
• 分子量: 329.433
• 闪点: 254.8±28.7 °C
• 精确质量: 329.199097
• PSA: 76.78000
• LogP: 3.61
• 外观性状: 黄褐色晶体
• 蒸汽压: 0.0±2.9 mmHg at 25°C
• 折射率: 1.610
• 储存条件: -20°C Freezer
• 水溶解性: 水溶性：不溶；微溶：二甲基甲酰胺；极微溶：甲醇,乙醇；不溶：二乙醚,氯仿

生物活性

• 描述: Trilostane(Win 24540; Modrastane)是3 β-羟化类固醇脱氢酶抑制剂,可作用于库兴氏综合征。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 内分泌
• 参考文献:

  [1]. Helm JR, et al. A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med. 2011 Mar-Apr;25(2):251-60.

  [2]. Feldman EC, et al. Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med. 2012 Jul-Aug;26(4):1078-80.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BV8044200 CHEMICAL NAME : 5-alpha-Androstane-2-alpha-carbonitrile, 4-alpha,5-epoxy-17-beta-hydroxy-3-oxo- CAS REGISTRY NUMBER : 13647-35-3 LAST UPDATED : 199603 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C20-H27-N-O3 MOLECULAR WEIGHT : 329.48 WISWESSER LINE NOTATION : T E5 D6663 1A R AX PV RO QHTTTT&J HQ I1 M1 OCN HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1055 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1637,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7050 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 102 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1205 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1637,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 109 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 54750 mg/kg/1Y-I TOXIC EFFECTS : Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1637,1986 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 48 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,754,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1050 mg/kg SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,754,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5 mg/kg SEX/DURATION : female 25-29 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 32,464,1979

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H315-H319-H361
• 警示性声明: P281-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38-62
• 安全声明 (欧洲): 26-36/37
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2937290090

海关

海关编码	2937290090