62869-69-6

• 常用中文名：1-Azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate
• 常用英文名：1-Azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate
• CAS号：62869-69-6
• 分子式：C₂₁H₂₃NO₃
• 分子量：337.41200
• 发布时间：2017-06-27 06:28:52
• 更新时间：2024-01-12 09:12:56
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名称

• 英文名: 1-Azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate
• 英文别名: L-quinuclidinyl benzilate; L-quinuclidinylbenzylate

物化性质

• 熔点: 164ºC
• 分子式: C₂₁H₂₃NO₃
• 分子量: 337.41200
• 精确质量: 337.16800
• PSA: 49.77000
• LogP: 2.49780

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301-H311-H331
• 警示性声明: P261-P280-P301 + P310-P311
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 风险声明 (欧洲): 23/24/25
• 安全声明 (欧洲): 22-36/37/39-45
• 危险品运输编码: UN 2811 6.1/PG 2
• RTECS号: DD4638000

合成路线

76-89-1 25333-42-0 ~% 62869-69-6

文献：ASTRAZENECA AB; ARGENTA DISCOVERY Ltd. Patent: WO2009/139710 A1, 2009 ; Location in patent: Page/Page column 43 ; WO 2009/139710 A1

141831-51-8 591-51-5 ~35% 62869-69-6

文献：Prat, Maria; Fernandez, Dolors; Buil, M. Antonia; Crespo, Maria I.; Casals, Gaspar; Ferrer, Manuel; Tort, Laia; Castro, Jordi; Monleon, Juan M.; Gavalda, Amadeu; Miralpeix, Montserrat; Ramos, Israel; Domenech, Teresa; Vilella, Dolors; Anton, Francisca; Huerta, Josep M.; Espinosa, Sonia; Lopez, Manuel; Sentellas, Sonia; Gonzalez, Marisa; Alberti, Joan; Segarra, Victor; Cardenas, Alvaro; Beleta, Jorge; Ryder, Hamish Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5076 - 5092

25333-42-0 52182-15-7 ~% 62869-69-6

文献：Rzeszotarski, W. Janusz; McPherson, Daniel W.; Ferkany, John W.; Kinnier, William J.; Noronha-Blob, Lalita; Kirkien-Rzeszotarski, Alicja Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1463 - 1466