298-00-0

298-00-0结构式

常用中文名：甲基对硫磷标准溶液
常用英文名：Parathion methyl
CAS号：298-00-0
分子式：C₈H₁₀NO₅PS
分子量：263.207
相关类别：化学农药原药杀虫剂有机磷杀虫剂
发布时间：2018-08-29 10:26:35
更新时间：2024-01-03 23:31:01
有机磷杀虫剂，用于防治水稻、棉花、果树、茶叶、蔬菜等害虫

中文名	甲基对硫磷
英文名	parathion-methyl
中文别名	甲基1605 甲基一六O五 O,O-二甲基-O-对硝基苯基硫代磷酸酯甲基一六0五甲基 1605 O,O-二甲基-O-(4-硝基苯基)硫代磷酸酯
英文别名	O,O-Dimethyl-O-(4-nitrophenyl)thiophosphat EINECS 206-050-1 gearphos Vofatox O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate Parathion methyl O,O-Dimethyl O-(p-nitrophenyl) thionophosphate Metaphos Dimethyl parathion dimethoxy-(4-nitrophenoxy)-sulfanylidene-λ<sup>5</sup>-phosphane Metacid O,O-Dimethyl O-(4-nitrophenyl) phosphorothioate Thiophosphate de O,O-diméthyle et de O-(4-nitrophényle) methyl parathion O,O-dimethyl O-4-nitrophenyl phosphorothioate MFCD00041813 O,O-dimethyl O-p-nitrophenyl phosphorothioate Metacid 50 dimethyl p-nitrophenyl thionophosphate BAY E 601 Me-parathion Parathion-methyl O,O-dimethyl O-(4-nitrophenyl) thiophosphate Dimethyl 4-nitrophenyl phosphorothionate Parataf O,O-Dimethyl O-p-nitrophenyl thiophosphate Penncap M Dalf Wofatox Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate

密度	1.4±0.1 g/cm3
沸点	334.7±44.0 °C at 760 mmHg
熔点	36°C
分子式	C₈H₁₀NO₅PS
分子量	263.207
闪点	156.2±28.4 °C
精确质量	263.001740
PSA	115.41000
LogP	2.78
外观性状	无色结晶粉末，工业品为棕色或黄色液体或固体。
蒸汽压	0.0±0.7 mmHg at 25°C
折射率	1.576
储存条件	储存注意事项储存于阴凉、通风良好的专用库房内，实行“双人收发、双人保管”制度。远离火种、热源。库温不宜超过30℃。包装密封。应与氧化剂、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.稳定性稳定 2.禁配物强氧化剂 3.避免接触的条件受热 4.聚合危害不聚合 5.分解产物氮氧化物、氧化硫、氧化磷
水溶解性	0.005 g/100 mL
分子结构	1、摩尔折射率：61.73 2、摩尔体积（cm³/mol）：186.5 3、等张比容（90.2K）：512.1 4、表面张力（dyne/cm）：56.8 5、极化率（10-24cm3）：24.47
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:6 4.可旋转化学键数量:4 5.互变异构体数量:无 6.拓扑分子极性表面积106 7.重原子数量:16 8.表面电荷:0 9.复杂度:279 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色结晶粉末，工业品为棕色或黄色液体或固体。 2.熔点（℃）：35 3.沸点（℃）：154（0.136kPa） 4.相对密度（水=1）：1.36 5.相对蒸气密度（空气=1）：9.1 6.辛醇/水分配系数：2.86 7.引燃温度（℃）：120 8.溶解性：微溶于水，溶于乙醇、氯仿，易溶于芳烃。

毒理学数据:

1.急性毒性

LD50：14~42mg/kg（大鼠经口）；63mg/kg（大鼠经皮）

LC50：34mg/m³（大鼠吸入，4h）

2.刺激性暂无资料

3.致突变性微生物致突变性：鼠伤寒沙门菌667μg/皿；大肠杆菌：10mmol/L。微核试验：大鼠腹腔注射2.5mg/kg（5d）。

4.致畸性大鼠孕后6~15d经口给予最低中毒剂量（TDLo）15mg/kg，致血液和淋巴系统发育畸形（包括脾和骨髓）。小鼠孕后11d腹腔内给予最低中毒剂量（TDLo）60mg/kg，致颅面部（包括鼻、舌）、肌肉骨骼系统发育畸形。

5.致癌性 IARC致癌性评论：G3，对人及动物致癌性证据不足。

6.其他小鼠腹腔注射最低中毒剂量（TDLo）：60mg/kg（孕11d用药），引起死胎，颅面部、骨骼肌肉发育异常。大鼠腹腔注射最低中毒剂量（TDLo）：15mg/kg（孕13d用药），引起胚胎发育迟缓。

生态学数据:

1.生态毒性

LC50：3.7mg/L（96h）（虹鳟鱼，静态）；9mg/L（96h）（金鱼）；7.13mg/L（96h）（鲤鱼，静态）；8.9mg/L（96h）（黑头呆鱼，静态）；4.38mg/L（96h）（蓝鳃太阳鱼，静态）

EC50：0.14μg/L（48h）（水蚤）

2.生物降解性

好氧生物降解（h）：360~1680

厌氧生物降解（h）：24~168

3.非生物降解性

水相光解半衰期（h）：192~912

水解最大光吸收波长范围（nm）：305~400

空气中光氧化半衰期（h）：1~10.5

一级水解半衰期（h）：1728

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TG0175000

CHEMICAL NAME :: Phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester

CAS REGISTRY NUMBER :: 298-00-0

BEILSTEIN REFERENCE NO. :: 1914724

LAST UPDATED :: 199712

DATA ITEMS CITED :: 100

MOLECULAR FORMULA :: C8-H10-N-O5-P-S

MOLECULAR WEIGHT :: 263.22

WISWESSER LINE NOTATION :: WNR B1 DOPS&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6010 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 mg/m3/4H

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/m3/4H

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9800 ug/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1270 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13200 ug/kg/6W-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation Kidney, Ureter, Bladder - incontinence

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg/26W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 ug/kg/15D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg/21W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 ug/m3/24H/93D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg/4W-C

TOXIC EFFECTS :: Liver - jaundice (or hyperbilirubinemia) hepatocellular Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg/30D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 42 mg/kg/12W-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 91 mg/kg/26W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 48 mg/kg/28D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 202 mg/kg/12D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: 20500 ug/kg/5D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 ug/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2200 ug/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 44 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,307,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal NO EVIDENCE IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,392,1987 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,131,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued. Volume(issue)/page/year: 14,141,1973 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,168,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.2 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.2 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.2 mg/m3;Skin JAN 1993 OEL-HUNGARY:TWA 0.1 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.2 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL PARATHION-air:10H TWA 0.2 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

符号	GHS02, GHS07, GHS09
信号词	Danger
危害声明	H225-H319-H336-H411
补充危害声明	Repeated exposure may cause skin dryness or cracking.
警示性声明	P210-P273-P280-P304 + P340 + P312-P337 + P313-P391
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	T+;N,N,T+,Xn,F
风险声明 (欧洲)	R5:Heating may cause an explosion. R24:Toxic in contact with skin. R26/28:Very Toxic by inhalation and if swallowed . R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed . R50/53:Very Toxic to aquatic organisms, may cause
安全声明 (欧洲)	S28-S36/37-S45-S60-S61-S26-S62
危险品运输编码	UN 2052/2783/2811
RTECS号	TG0175000
包装等级	II
危险类别	6.1(a)
海关编码	2920110000

100-02-7

2524-03-0

298-00-0

文献：Journal of the American Chemical Society, , vol. 72, p. 2461,2463

2524-03-0

824-78-2

298-00-0

文献：Tetrahedron, , vol. 51, # 29 p. 7981 - 7992

28341-54-0

124-41-4

298-00-0

文献：US2663721 , ;

上游产品 5
100-02-7 2524-03-0 824-78-2 28341-54-0
124-41-4
下游产品 10
100-02-7 152-20-5 950-35-6 131-11-3
472-41-3 123-31-9 507-09-5 16604-77-6
597-89-7 58175-57-8

1.由O，O-二甲基硫化磷酰氯在溶剂中与对硝基苯酚缩合而得。将二甲苯和对硝基酚钠在96℃（73.3-76.0kPa）以下共沸脱水2-3h，加入碳酸钠和铜粉，升温至90℃左右，滴加O，O-二甲基硫代磷酰氯。加毕，搅拌保温2-3h。冷却至50℃，过滤，用少量二甲苯冲洗滤渣，滤液用5%碳酸钠溶液洗至无色，再用饱和食盐水洗至中性，分出油层，减压蒸出二甲苯，即得甲基对硫磷原油。原药为浅黄色至浅棕色液体或固体。原料消耗定额：黄磷210kg/t；氯气690kg/t；硫黄200kg/t；甲醇600kg/t；对硝基酚钠730kg/t。

海关编码	2920110000

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4