85466-18-8

• 常用中文名：查摸丁卡
• 常用英文名：Thymopoietin II: 32-35
• CAS号：85466-18-8
• 分子式：C₂₁H₄₀N₈O₇
• 分子量：516.59200
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-03-20 08:00:00
• 更新时间：2025-08-22 16:17:05
• 胸腺生成素(胸腺生成素II(32-35))是胸腺因子(胸腺生成肽)的32-35片段。Thymocartin已显示出在免疫缺陷疾病研究中的潜力[1][2]。

名称

• 中文名: 查摸丁卡
• 英文名: (2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
• 中文别名: GLY-GLU-GLN-ARG-LYS-ASP-VAL-TYR-VAL-GLN-LEU-TYR-LEU: GENRKDVYVQLYL; 胸腺卡汀
• 英文别名: Rgh 0206; Thymocartina [INN-Spanish]; Thymocartine [INN-French]; Thymocartinum [INN-Latin]; Thymocartina; Thymocartin; Thymopoietin II: 32-35

物化性质

• 密度: 1.45g/cm3
• 分子式: C₂₁H₄₀N₈O₇
• 分子量: 516.59200
• 精确质量: 516.30200
• PSA: 275.84000
• LogP: 1.13990
• 折射率: 1.619

生物活性

• 描述: 胸腺生成素(胸腺生成素II(32-35))是胸腺因子(胸腺生成肽)的32-35片段。Thymocartin已显示出在免疫缺陷疾病研究中的潜力[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. S Lang, et al. Transport and metabolic pathway of thymocartin (TP4) in excised bovine nasal mucosa. J Pharm Pharmacol. 1996 Nov;48(11):1190-6.

  [2]. Ch B Felder, et al. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters. J Microencapsul. 2003 Sep-Oct;20(5):553-67.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YV9384000 CHEMICAL NAME : L-Valine, N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)- CAS REGISTRY NUMBER : 85466-18-8 LAST UPDATED : 199410 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C21-H40-N8-O7 MOLECULAR WEIGHT : 516.69 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986