620175-39-5

• 常用中文名：AFN-1252
• 常用英文名：AFN-1252
• CAS号：620175-39-5
• 分子式：C₂₂H₂₁N₃O₃
• 分子量：375.42000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2017-01-08 12:55:05
• 更新时间：2024-01-29 16:55:44
• AFN-1252(Debio 1452)是FabI高效抑制剂,能抑制金黄色葡萄球菌。

名称

• 中文名: AFN-1252
• 英文名: (E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide
• 英文别名: afn-1252; unii-t3o718ikkm; api-1252

物化性质

• 分子式: C₂₂H₂₁N₃O₃
• 分子量: 375.42000
• 精确质量: 375.15800
• PSA: 78.93000
• LogP: 3.77780
• 储存条件: 2-8℃

生物活性

• 描述: AFN-1252(Debio 1452)是FabI高效抑制剂,能抑制金黄色葡萄球菌。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.

  [2]. Narasimha Rao K, et al. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40.

  [3]. Yao J, et al. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71.

  [4]. Parsons JB, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013 May;57(5):2182-90.