1223-36-5

• 常用中文名：氯非沙胺
• 常用英文名：2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
• CAS号：1223-36-5
• 分子式：C₁₄H₂₁ClN₂O₂
• 分子量：284.78200
• 发布时间：2018-06-01 08:00:00
• 更新时间：2025-08-25 17:42:35

名称

• 中文名: 氯非沙胺
• 英文名: 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
• 英文别名: ANP 246; Clofexamide; EINECS 214-951-6; IEM 455; Amichlophene; Chlofexamide; NP 246; 4-Chlorphenoxyessigsaeure-<2-diethylaminoethylamid>

物化性质

• 密度: 1.12g/cm3
• 沸点: 449.7ºC at 760 mmHg
• 分子式: C₁₄H₂₁ClN₂O₂
• 分子量: 284.78200
• 闪点: 225.8ºC
• 精确质量: 284.12900
• PSA: 41.57000
• LogP: 2.56770
• 蒸汽压: 2.81E-08mmHg at 25°C
• 折射率: 1.522
• 储存条件: 库房低温,通风,干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AB5822500 CHEMICAL NAME : Acetamide, 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl)- CAS REGISTRY NUMBER : 1223-36-5 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C14-H21-Cl-N2-O2 MOLECULAR WEIGHT : 284.82 WISWESSER LINE NOTATION : GR DO1VM2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1040 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,935,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 290 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,154,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 167 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M

安全

• 海关编码: 2924299090

合成路线

100-36-7 4122-68-3 ~% 1223-36-5

文献：Thuillier,G.; Rumpf,P. Bulletin de la Societe Chimique de France, 1960 , p. 1786 - 1794

122-88-3 ~% 1223-36-5

文献：Thuillier,G.; Rumpf,P. Bulletin de la Societe Chimique de France, 1960 , p. 1786 - 1794

14426-42-7 100-36-7 ~% 1223-36-5

文献：Thuillie,G. Chimica Therapeutica, 1966 , vol. 1, p. 82 - 86

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%