55881-07-7

• 常用中文名：醋酸麦迪霉素
• 常用英文名：Midecamycin acetate
• CAS号：55881-07-7
• 分子式：C₄₅H₇₁NO₁₇
• 分子量：898.04200
• 相关类别： 原料药 抗生素类药物 大环内酯类药
• 发布时间：2018-05-27 08:00:00
• 更新时间：2024-01-09 17:35:34
• Miocamycin (Midecamycin acetate) 是一种 midecamycin (HY-B1908) 的衍生物。Miocamycin 具有抗菌特性。

名称

• 中文名: 醋酸麦迪霉素
• 英文名: Midecamycin Acetate
• 中文别名: 乙酸米地加黴素
• 英文别名: Acecamycin; 9,3''-di-O-acetylmidecamycin; Ponsinomycin; Mom; 9,3''-diacetylmidecamycin; Miocamycin; Miokamycin; 3',9-Diacetylmydecamycin

物化性质

• 密度: 1.2 g/cm3
• 沸点: 878.7ºC at 760 mmHg
• 熔点: ~220° (with coloration)
• 分子式: C₄₅H₇₁NO₁₇
• 分子量: 898.04200
• 闪点: 485.2ºC
• 精确质量: 897.47200
• PSA: 218.19000
• LogP: 3.90900
• 外观性状: 白色或灰白色结晶粉末
• 折射率: 1.524

生物活性

• 描述: Miocamycin (Midecamycin acetate) 是一种 midecamycin (HY-B1908) 的衍生物。Miocamycin 具有抗菌特性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN). July 1984. Volume 37 Issue 7 Pages 1355-1375.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OH4730020 CHEMICAL NAME : Leucomycin V, 3(sup B),9-diacetate 3,4(sup B)-dipropanoate CAS REGISTRY NUMBER : 55881-07-7 LAST UPDATED : 199806 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C45-H71-N-O17 MOLECULAR WEIGHT : 898.17 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1331,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 37,1565,1984 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 37,1313,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 37,1565,1984