184046-78-4

• 常用中文名：(2S,3S)-3-羟基-1,2-吡咯烷二羧酸 1-叔丁酯 2-甲基酯
• 常用英文名：(2S,3S)-1-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE-2-CARBOXYLICACIDMETHYLESTER
• CAS号：184046-78-4
• 分子式：C₁₁H₁₉NO₅
• 分子量：245.27200
• 发布时间：2018-12-25 11:48:06
• 更新时间：2025-08-25 19:31:21

名称

• 中文名: (2S,3S)-3-羟基-1,2-吡咯烷二羧酸 1-叔丁酯 2-甲基酯
• 英文名: 1-O-tert-butyl 2-O-methyl (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate
• 中文别名: (2S,3s)-1-(叔丁氧基羰基)-3-羟基吡咯烷-2-羧酸甲酯
• 英文别名: BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER; VT1198; N-tert-butoxycarbonyl-trans-3-hydroxy-L-proline methyl ester; (2S,3S)-N-tert-butoxycarbonyl-3-hydroxy-2-pyrrolidine carboxylic acid methyl ester; (2S,3S)-N-tert-butyloxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic acid methyl ester; (2S,3S)-1-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER; (2S,3S)-1-tert-butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate; (2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxyproline methyl ester; N-tert-butoxycarbonyl-(2S,3S)-3-hydroxyproline methyl ester; N-(TERT-BUTOXYCARBONYL)-(3S)-HYDROXY-L-PROLINE METHYL ESTER; methyl 1-(tert-butoxycarbonyl)-(3S)-hydroxypyrrolidine-2-carboxylate

物化性质

• 密度: 1.216
• 沸点: 335.2ºC at 760 mmHg
• 分子式: C₁₁H₁₉NO₅
• 分子量: 245.27200
• 闪点: 156.6ºC
• 精确质量: 245.12600
• PSA: 76.07000
• LogP: 0.46760
• 蒸汽压: 8.47E-06mmHg at 25°C
• 折射率: 1.5

合成路线

24424-99-5 ~% 184046-78-4

文献：Sun, Chong-Qing; Hamann, Lawrence; Augeri, David; Bi, Yingzhi; Robl, Jeffrey; Huang, Yan-Ting; Wang, Tammy; Holubec, Alexandra; Simpkins, Ligaya; Sutton, James C.; Li, James J. Patent: US2004/181064 A1, 2004 ; US 20040181064 A1

4298-08-2 ~% 184046-78-4

文献：Gomez-Vidal, Jose A.; Silverman, Richard B. Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484

186581-53-3 187039-57-2 ~96% 184046-78-4

文献：Gomez-Vidal, Jose A.; Silverman, Richard B. Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484

24424-99-5 496841-04-4 ~80% 184046-78-4

文献：Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7280 - 7282

187039-57-2 18107-18-1 ~99% 184046-78-4

文献：Vicuron Pharmaceuticals Inc. Patent: US2010/22605 A1, 2010 ; Location in patent: Page/Page column 16; 33; 36 ; US 20100022605 A1

58632-95-4 ~% 184046-78-4

文献：Gomez-Vidal, Jose A.; Silverman, Richard B. Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484

187039-57-2 74-88-4 ~86% 184046-78-4

文献：TETRALOGIC PHARMACEUTICALS CORP.; CONDON, Stephen, M.; LAPORTE, Matthew, G. Patent: WO2010/33531 A1, 2010 ; Location in patent: Page/Page column 66 ;

上下游产品

上游产品  8
187039-57-2 74-88-4 24424-99-5 4298-08-2
186581-53-3 496841-04-4 18107-18-1 58632-95-4
下游产品  4
186132-96-7 261350-70-3 13726-69-7 496841-07-7