171596-43-3

• 常用中文名：(1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯
• 常用英文名：(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester
• CAS号：171596-43-3
• 分子式：C₂₀H₁₈N₂O₄
• 分子量：350.36800
• 发布时间：2017-11-27 01:24:35
• 更新时间：2025-08-28 11:15:39

名称

• 中文名: (1S,3S)-1-(1,3-苯并二氧戊环-5-基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸甲酯
• 英文名: Methyl (1S,3S)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-β-c arboline-3-carboxylate
• 英文别名: trans-3-Aminocyclopentanecarboxylic acid; (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester; Tadalafil Impurity 3; Tadalafil Impurity 11

物化性质

• 分子式: C₂₀H₁₈N₂O₄
• 分子量: 350.36800
• 精确质量: 350.12700
• PSA: 72.58000
• LogP: 3.00210

合成路线

120-57-0 64-17-5 73-22-3 ~% 171596-44-4 详细

文献：LEK Pharmaceuticals d.d. Patent: EP2107059 A1, 2009 ; Location in patent: Page/Page column 9 ;

120-57-0 4299-70-1 ~36% 171596-44-4 171596-43-3

文献：Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542

120-57-0 7524-52-9 ~95% 171596-43-3

文献：Xiao, Sen; Shi, Xiao-Xin; Xing, Jing; Yan, Jing-Jing; Liu, Shi-Ling; Lu, Wei-Dong Tetrahedron Asymmetry, 2009 , vol. 20, # 18 p. 2090 - 2096

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