555-29-3

• 常用中文名：DL-甲基多巴
• 常用英文名：3-Hydroxy-alpha-methyl-DL-tyrosine
• CAS号：555-29-3
• 分子式：C₁₀H₁₃NO₄
• 分子量：211.214
• 发布时间：2018-07-29 15:07:18
• 更新时间：2024-01-12 07:59:40

名称

• 中文名: DL-甲基多巴
• 英文名: 2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
• 中文别名: 3-羟基-alpha-甲基-DL-酪氨酸; 2-甲基-3-(3,4-二羟基苯基)-DL-丙氨酸
• 英文别名: a-Methyl-L-dopa; α-Methyl-L-dopa; Dopegyt; EINECS 209-088-7; 3-(3,4-Dihydroxyphenyl)-2-methyl alanine; L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine; L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine; L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine; rac Alpha-Methyl DOPA; 2-Methyl-3-(3,4-dihydroxyphenyl)-DL-alanine; a-Methyl Dopa; (+)-α-Methyldopa; Mulfasin; UNII:33TD13T99R; α-Methyl dopa; 3-Hydroxy-α-methyltyrosine; Metholes; Tyrosine, 3-hydroxy-α-methyl-; L-(a-Md); L-α-Methyldopa; (-)-α-Methyldopa; 3-Hydroxy-α-methyl-L-tyrosine; L-Tyrosine, 3-hydroxy-α-methyl-; Dopamet; (S)-(-)-a-Methyldopa; a-Methyl-b-(3,4-dihydroxyphenyl)-L-alanine; Bayer 1440L; MFCD00065917; Methyl dopa; Aldomet; l-a-Methyldopa; (S)-a-Methyldopa; ALDORIL; Alanine, 3- (3,4-dihydroxyphenyl)-2-methyl-, L-; Methyldopa; L-a-Methyl-3,4-dihydroxyphenylalanine; (-)-Methyldopa; Elanpres

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 441.6±45.0 °C at 760 mmHg
• 分子式: C₁₀H₁₃NO₄
• 分子量: 211.214
• 闪点: 220.9±28.7 °C
• 精确质量: 211.084457
• PSA: 103.78000
• LogP: 0.13
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.635
• 储存条件: −20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AY5940000 CHEMICAL NAME : Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DL- CAS REGISTRY NUMBER : 555-29-3 LAST UPDATED : 199403 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C10-H13-N-O4 MOLECULAR WEIGHT : 211.24 WISWESSER LINE NOTATION : QVXZ1&1R CQ DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5370 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1317 mg/kg TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1318,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1760 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26-36/37
• WGK德国: 3