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78247-49-1生产厂家

78247-49-1价格

78247-49-1

78247-49-1结构式
78247-49-1结构式
  • 常用中文名:愈创木酚磺酸钾
  • 常用英文名:Potassium guaiacolsulfonate hemihydrate
  • CAS号:78247-49-1
  • 分子式:C7H8O5S.1/2H2O.K
  • 分子量:502.597
  • 相关类别: 原料药 呼吸系统用药 祛痰药
  • 发布时间:2018-06-28 18:17:25
  • 更新时间:2024-01-02 12:38:48
  • Potassium guaiacolsulfonate hemihydrate 是一种具有口服活性祛痰剂,可用于急性呼吸道感染。Potassium guaiacolsulfonate hemihydrate 有助于松弛粘液,与其他药物合用,可用于由普通感冒,感染或过敏引起的咳嗽。

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中文名 愈创木酚磺酸钾
英文名 Potassium guaiacolsulfonate hemihydrate
中文别名 创木酚磺酸钾.
英文别名 POTASSIUMGUAIACOLSULFONATE,USP
Potassium hydroxymethoxybenzenesulfonate hemihydrate
hydroxymethoxy-benzenesulfonicacimonopotassiumsalt
PotassiuM guaiacolsulfonate heMihydrate API
PATSSIUMGUAIACOLSULFONATE
POTASSIUM GUAIACOLSULFONATE HYDRATE
Potassium 4-hydroxy-3-methoxybenzenesulfonate hydrate (2:2:1)
Benzenesulfonic acid, 4-hydroxy-3-methoxy-, potassium salt, hydrate (2:2:1)
PotassiuM Guaiacolsulfonate,HeMihydrate,USP
描述 Potassium guaiacolsulfonate hemihydrate 是一种具有口服活性祛痰剂,可用于急性呼吸道感染。Potassium guaiacolsulfonate hemihydrate 有助于松弛粘液,与其他药物合用,可用于由普通感冒,感染或过敏引起的咳嗽。
相关类别
体外研究 愈创木酚磺酸钾半水合物的作用是稀释肺部的粘液(痰),使其不那么粘稠,更容易咳嗽[1]。
参考文献

[1]. Thi Huong Hoa Le, et al. Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder. J Anal Methods Chem. 2019 Mar 7;2019:6143061.

[2]. Ozlem Aksu Dönmez, et al. Simultaneous Determination of Potassium Guaiacolsulfonate, Guaifenesin, Diphenhydramine HCl and Carbetapentane Citrate in Syrups by Using HPLC-DAD Coupled With Partial Least Squares Multivariate Calibration. Talanta. 2011 Feb 15;83(5):1601-5.

分子式 C7H8O5S.1/2H2O.K
分子量 502.597
精确质量 501.940826
PSA 199.31000
LogP 2.70710
储存条件 -20°C

Section 1. Chemical Product and Company Identification
Potassium GuaiacolsulfonateCatalog
PO179
Common Name/
Number(s).
Trade Name
CAS#1321-14-8
Manufacturer
RTECSNot available.
SPECTRUM CHEMICAL MFG. CORP.
TSCATSCA 8(b) inventory:
Potassium Guaiacolsulfonate
Commercial Name(s)Not available.
CI# Not available.
SynonymNot available.
IN CASE OF EMERGENCY
Potassium Guaiacolsulfonate
Chemical Name
Chemical FamilyNot available.CALL (310) 516-8000
C7-H7-K-O5-S.1/2H2O
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.

Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3)
NameCAS #% by Weight
1) Potassium Guaiacolsulfonate1321-14-8100
Toxicological DataPotassium Guaiacolsulfonate
on IngredientsLD50: Not available.
LC50: Not available.

Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic HealthCARCINOGENIC EFFECTS: Not available.
EffectsMUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Potassium Guaiacolsulfonate

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
keeping eyelids open. WARM water MUST be used. Do not use an eye ointment. Seek medical attention.
Skin ContactAfter contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated
clothing before reusing.
Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious InhalationNot available.
IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...). Some metallic oxides.
Products of Combustion
Fire Hazards in Presence of Not available.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available.
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onNot available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Potassium Guaiacolsulfonate

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable
protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek
medical attention and show the label when possible. Avoid contact with skin and eyes
StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline solid.)OdorOdorless.
TasteNot available.
251.29 g/mole
Molecular Weight
ColorNot available.
pH (1% soln/water)Not available.
Boiling PointNot available.
Melting PointNot available.
Critical TemperatureNot available.
Specific Gravity1.4 (Water = 1)
Not applicable.
Vapor Pressure
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Water/Oil Dist. Coeff.Not available.
Not available.
Ionicity (in Water)
Dispersion PropertiesDispersed in cold water.
Not available.
Solubility

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Not available.
Conditions of Instability
Incompatibility with various Not available.
substances
Potassium Guaiacolsulfonate
CorrosivityNot available.
Special Remarks onNot available.
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationNot available.

Section 11. Toxicological Information
Routes of EntryAbsorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects onHazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onNot available.
Chronic Effects on Humans
Special Remarks on otherNot available.
Toxic Effects on Humans

Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the ProductsThe product itself and its products of degradation are not toxic.
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation

Section 13. Disposal Considerations
Waste Disposal

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
IdentificationNot applicable.
Special Provisions forNot applicable.
Transport
Potassium Guaiacolsulfonate
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Potassium Guaiacolsulfonate
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsNot available..
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC)R36/38- Irritating to eyes and skin.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Potassium Guaiacolsulfonate


SECTION 16 - ADDITIONAL INFORMATION
N/A
危险品运输编码 NONH for all modes of transport
海关编码 2909500000
海关编码 2909500000
中文概述 2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%