517-09-9

• 常用中文名：马萘雌甾酮
• 常用英文名：equilenin
• CAS号：517-09-9
• 分子式：C₁₈H₁₈O₂
• 分子量：266.33400
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-08-02 16:59:59
• 更新时间：2024-01-03 22:12:30
• Equilenin is an equine estrogen found in the urine of pregnant mares. Equilenin is also a naturally fluorescent steroid, has high binding affinity for human sex steroid-binding protein (SBP). At 4 degrees C the equilibrium association constant is approximately 6 X 10(7) M-1.

名称

• 中文名: 马萘雌甾酮
• 英文名: (13S,14S)-3-hydroxy-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-17-one
• 中文别名: 雌马甾酮
• 英文别名: Equilenin solution; EQU; Equilenina; d-Equilenin

物化性质

• 密度: 1.242g/cm3
• 沸点: 472.6ºC at 760mmHg
• 熔点: 258-259°
• 分子式: C₁₈H₁₈O₂
• 分子量: 266.33400
• 闪点: 200.9ºC
• 精确质量: 266.13100
• PSA: 37.30000
• LogP: 3.94440
• 折射率: 1.662

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG6125000 CHEMICAL NAME : Estra-1,3,5,7,9-pentaen-17-one, 3-hydroxy- CAS REGISTRY NUMBER : 517-09-9 BEILSTEIN REFERENCE NO. : 2335367 LAST UPDATED : 199709 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H18-O2 MOLECULAR WEIGHT : 266.36 WISWESSER LINE NOTATION : L E5 B666 FVTT&&J E1 OQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1600 ug/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors REFERENCE : BSBSAS Boletin de la Sociedad de Biologia de Santiago de Chile. (Santiago, Chile) V.1-12, 1943-55. Discontinued. Volume(issue)/page/year: 8,142,1951 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 640 mg/kg/38W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5200,1983 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors REFERENCE : RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology. (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro, Brazil) V.1- 1941- Volume(issue)/page/year: 5,1,1945

安全

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302-H312-H319-H332
• 警示性声明: P210-P280-P305 + P351 + P338
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): F,Xn
• 风险声明 (欧洲): 11-20/21/22-36
• 安全声明 (欧洲): 16-26-36-36/37
• 危险品运输编码: UN 1648 3/PG 2

合成路线

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