4546-39-8

• 常用中文名：哌沙酯
• 常用英文名：Piperilate
• CAS号：4546-39-8
• 分子式：C₂₁H₂₅NO₃
• 分子量：339.42800
• 相关类别： 信号通路 神经信号通路 疼痛
• 发布时间：2018-05-18 08:00:00
• 更新时间：2024-01-09 19:24:20
• 哌啶酸盐(哌乙酸酯)是一种hetrazepine衍生物PAF拮抗剂与抗胆碱能药物的混合物,可用于支气管哮喘研究。胡椒酸盐也会引起低血压,并拯救有机磷酸盐中毒的小鼠[1][2][3]。

名称

• 中文名: 哌沙酯
• 英文名: 2-piperidin-1-ylethyl 2-hydroxy-2,2-diphenylacetate
• 英文别名: Pipethanatum [INN-Latin]; 2-(1-Piperidino)ethyl benzilate; Pipetanato [INN-Spanish]; Piperilate; Benzilsaeure-(2-piperidino-aethylester); pipethanate; BENZILIC ACID,2-PIPERIDINOETHYL ESTER; Benzilsaeure-<2-piperidino-ethylester>; 1-Piperidineethanol benzilate

物化性质

• 密度: 1.155 g/cm3
• 沸点: 444.1ºC at 760mmHg
• 分子式: C₂₁H₂₅NO₃
• 分子量: 339.42800
• 闪点: 222.4ºC
• 精确质量: 339.18300
• PSA: 49.77000
• LogP: 2.88950
• 折射率: 1.574

生物活性

• 描述: 哌啶酸盐(哌乙酸酯)是一种hetrazepine衍生物PAF拮抗剂与抗胆碱能药物的混合物,可用于支气管哮喘研究。胡椒酸盐也会引起低血压,并拯救有机磷酸盐中毒的小鼠[1][2][3]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 神经信号通路 >> 疼痛
• 体内研究: 胡椒酸盐(11.3 mg/kg,29.42 mg/kg；腹腔注射；单次剂量)显示出抗胆碱能活性,而(30 mg/kg；静脉注射；单剂量)对有机磷酸盐中毒的小鼠有疗效[1]。胡椒酸盐(1 mg/kg；静脉注射)可引起兔低血压,二氯异丙醇或阿托品(HY-B1205)不会阻断低血压[2]。胡椒酸盐(3 mg/kg；静脉注射)降低试验兔的呼吸和心率,阻断肾上腺素(HY-122304)诱导的兔耳廓离体制剂收缩[2]。动物模型：雄性白化小鼠(18-22 g)[1]剂量：11.3 mg/kg,29.42 mg/kg给药：腹腔注射；单剂量结果：在小鼠中显示出抗胆碱能活性,EC50值为11.33 mg/kg(拮抗氧三甲胺诱导的流涎)和29.42 mg/kg(对抗氧三甲铵诱导的震颤)。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DD4198000 CHEMICAL NAME : Benzilic acid, 2-piperidinoethyl ester CAS REGISTRY NUMBER : 4546-39-8 BEILSTEIN REFERENCE NO. : 0385167 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H25-N-O3 MOLECULAR WEIGHT : 339.47 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 510 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 162 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969

安全

• 海关编码: 2933399090

合成路线

2008-75-5 ~% 4546-39-8

文献：Blicke; Maxwell Journal of the American Chemical Society, 1942 , vol. 64, p. 431 Full Text View citing articles Show Details Ford-Moore; Ing Journal of the Chemical Society, 1947 , p. 59

1932-03-2 76-93-7 ~% 4546-39-8

文献：Blicke; Maxwell Journal of the American Chemical Society, 1942 , vol. 64, p. 431

3040-44-6 52182-15-7 ~% 4546-39-8

文献：Am. Cyanamid Co. Patent: US2394770 , 1942 ;

上下游产品

上游产品  5
2008-75-5 1932-03-2 76-93-7 3040-44-6
52182-15-7
下游产品  0

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%