490-98-2

• 常用中文名：羟丁卡因
• 常用英文名：Hydroxytetracaine
• CAS号：490-98-2
• 分子式：C₁₅H₂₄N₂O₃
• 分子量：280.36300
• 发布时间：2018-09-28 17:33:26
• 更新时间：2025-08-23 15:29:11

名称

• 中文名: 羟丁卡因
• 英文名: 2-(dimethylamino)ethyl 4-(butylamino)-2-hydroxybenzoate
• 英文别名: Salicacaine; Oxypentocain; Salicain; Idrossitetracaina [DCIT]; Oxitetracainum; 4-Butylamino-2-hydroxy-benzoesaeure-(2-dimethylamino-aethylester); Salicaine (anesthetic); Hydroxytetracain; Hydroxamethocaine; Rhenocain; Hydroxytetracainum [INN-Latin]; 4-butylamino-2-hydroxy-benzoic acid-(2-dimethylamino-ethyl ester); Hydroxytetracaine

物化性质

• 密度: 1.114g/cm3
• 沸点: 415.1ºC at 760mmHg
• 分子式: C₁₅H₂₄N₂O₃
• 分子量: 280.36300
• 闪点: 204.9ºC
• 精确质量: 280.17900
• PSA: 61.80000
• LogP: 2.39560
• 蒸汽压: 1.76E-07mmHg at 25°C
• 折射率: 1.557

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VO1932000 CHEMICAL NAME : Salicylic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester CAS REGISTRY NUMBER : 490-98-2 BEILSTEIN REFERENCE NO. : 2125583 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H24-N2-O3 MOLECULAR WEIGHT : 280.41 WISWESSER LINE NOTATION : 4MR DQ CVO2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intratracheal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 2,112,1952 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,40,1952

合成路线

3688-00-4 123-72-8 ~% 490-98-2

文献：Rheinpreussen A.G. Patent: DE941849 , 1951 ;

619-19-2 ~% 490-98-2

文献：Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

101084-96-2 ~% 490-98-2

文献：Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

78987-51-6 ~% 490-98-2

文献：Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

65-49-6 ~% 490-98-2

文献：Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742

94479-64-8 107-99-3 ~% 490-98-2

文献：Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742

上下游产品

上游产品  6
123-72-8 619-19-2 101084-96-2 78987-51-6
65-49-6 107-99-3
下游产品  0