Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hydroxytetracaine
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Purity: 98.0%
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490-98-2

490-98-2 structure

Name: Hydroxytetracaine
Chemical Name: 2-(dimethylamino)ethyl 4-(butylamino)-2-hydroxybenzoate
CAS Number: 490-98-2
Molecular Formula: C₁₅H₂₄N₂O₃
Molecular Weight: 280.36300
Create Date: 2018-09-28 17:33:26
Modify Date: 2024-01-10 23:13:19

Name	2-(dimethylamino)ethyl 4-(butylamino)-2-hydroxybenzoate
Synonyms	Salicacaine Oxypentocain Salicain Idrossitetracaina [DCIT] Oxitetracainum 4-Butylamino-2-hydroxy-benzoesaeure-(2-dimethylamino-aethylester) Salicaine (anesthetic) Hydroxytetracain Hydroxamethocaine Rhenocain Hydroxytetracainum [INN-Latin] 4-butylamino-2-hydroxy-benzoic acid-(2-dimethylamino-ethyl ester) Hydroxytetracaine

Density	1.114g/cm3
Boiling Point	415.1ºC at 760mmHg
Molecular Formula	C₁₅H₂₄N₂O₃
Molecular Weight	280.36300
Flash Point	204.9ºC
Exact Mass	280.17900
PSA	61.80000
LogP	2.39560
Vapour Pressure	1.76E-07mmHg at 25°C
Index of Refraction	1.557

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1932000

CHEMICAL NAME :: Salicylic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester

CAS REGISTRY NUMBER :: 490-98-2

BEILSTEIN REFERENCE NO. :: 2125583

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H24-N2-O3

MOLECULAR WEIGHT :: 280.41

WISWESSER LINE NOTATION :: 4MR DQ CVO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 2,112,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,40,1952

3688-00-4

123-72-8

490-98-2

Literature: Rheinpreussen A.G. Patent: DE941849 , 1951 ;

619-19-2

490-98-2

Literature: Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

101084-96-2

490-98-2

Literature: Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

78987-51-6

490-98-2

Literature: Clinton et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3674,3678

65-49-6

490-98-2

Literature: Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742

94479-64-8

107-99-3

490-98-2

Literature: Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742

Precursor 6
123-72-8 619-19-2 101084-96-2 78987-51-6
65-49-6 107-99-3
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4